Results 51 to 60 of about 300,540 (311)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A New Type of Soft Group: Soft Symmetric Difference Group with Group Theory Applications
MathematicsIn this paper, a new type of soft group called the soft symmetric difference group (SSD-group) is introduced and systematically developed. This structure is constructed by integrating soft set theory with group theory through the symmetric difference ...
Aslıhan Sezgin +2 more
doaj +1 more source
The State-of-the-Art of Set Visualization [PDF]
, 2016 Sets comprise a generic data model that has been used in a variety of data analysis problems. Such problems involve analysing and visualizing set relations between multiple sets defined over the same collection of elements. However, visualizing sets is a
Alsallakh, Bilal +11 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Engineering Transactions, 2014 The main objective of the present paper is the consistent development of the thermody- namical theory of elasto-viscoplasticity within the framework of a unique constitutive material structure.
Piotr PERZYNA
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
BMC Medical Education, 2019 Background Community-based education (CBE) involves educating the head (cognitive), heart (affective), and the hand (practical) by utilizing tools that enable us to broaden and interrogate our value systems.
Mpho S. Mogodi +4 more
doaj +1 more source
Internal Set Theory IST# Based on Hyper Infinitary Logic with Restricted Modus Ponens Rule: Nonconservative Extension of the Model Theoretical NSA [PDF]
, 2022 The incompleteness of set theory ZF C leads one to look for natural nonconservative extensions of ZF C in which one can prove statements independent of ZF C which appear to be “true”. One approach has been to add large cardinal axioms.
Foukzon, Jaykov
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source