Results 81 to 90 of about 12,247,654 (298)

From Resilience to Transformation: the Adaptive Cycle in Two Mexican Urban Centers

open access: yesEcology and Society, 2011
Climate change is but one expression of the internal contradictions of capitalism that include also economic inequality and political alienation. Seen in this way analysis of human responses to climate change must engage with social relations of power ...
Mark Pelling, David Manuel-Navarrete
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

AUDIT – ASSESSMENT, INSPECTION OR CONTROL? [PDF]

open access: yesAnnals of the University of Petrosani: Economics, 2016
The emergence audit concept has created a lot of confusion, on the one hand between its manifestations, on the other hand between it and the indigenous concepts that are more suggestive and at the same time more explicit.
CONSTANŢA IACOB   +1 more
doaj  

Psalm 29 as Semiotic System: A Linguistic Reading

open access: yesJournal of Hebrew Scriptures, 2009
This study is an attempt to read Psalm 29 through the interpretive lens of insights taken from Czech structuralist and Russian Formalist literary theory.
James M. Kennedy
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

A random set and prototype theory interpretation of intuitionistic fuzzy sets [PDF]

open access: yes, 2010
An interpretation of intuitionistic fuzzy sets is proposed based on random set theory and prototype theory. The extension of fuzzy labels are modelled by lower and upper random set neighbourhoods, identifying those element of the universe within an ...
Lawry, Jonathan, Jonathan Lawry
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

Set-based design of mechanical systems with design robustness integrated [PDF]

open access: yes, 2014
This paper presents a method for parameter design of mechanical products based on a set-based approach. Set-based concurrent engineering emphasises on designing in a multi-stakeholder environment with concurrent involvement of the stakeholders in the ...
DANTAN, Jean-Yves   +3 more
core   +1 more source

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