Results 61 to 70 of about 824,640 (257)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of Surface Layers in Sliding Contact of Viscoelastic Solids (3-D Model of Material)

open access: yesFrontiers in Mechanical Engineering, 2019
Sliding contact of a smooth indenter and a two-layered half-space is considered to take rheological properties of materials into account. A viscoelastic layer bonded with a rigid half-space is analyzed as well as the opposite viscoelastic half-space ...
Elena V. Torskaya, Fedor I. Stepanov
doaj   +1 more source

Metal tube used as solar engine [PDF]

open access: yes, 1973
Ends of metal tube are fastened to axles which are supported on bearings so tube can rotate about its long axis while subjected to invariant bending moment that stresses it along longitudinal axis of rotation.
Beam, R. M.   +2 more
core   +1 more source

Shakedown and limit analysis of 90° pipe bends under internal pressure, cyclic in-plane bending and cyclic thermal loading [PDF]

open access: yes, 2011
The Linear Matching Method is used to create the shakedown limit and limit load interaction curves of 90 degree pipe bends for a range of bend factors.
Chen, Haofeng   +4 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Effect of collagen-induced residual stress on the frictional property of articular cartilage

open access: yesBiosurface and Biotribology, 2018
Previous findings, such as split-line of the articular cartilage surface and curving of sliced cartilage specimen, would suggest that residual stress is contained in articular cartilage.
Hiromichi Fujie   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Towards good practice guidelines for the contour method of residual stress measurement

open access: yesThe Journal of Engineering, 2014
Accurate measurement of residual stress in metallic components using the contour method relies on the achievement of a good quality cut, on the appropriate measurement of the deformed cut surface and on the robust analysis of the measured data.
Foroogh Hosseinzadeh   +2 more
doaj   +1 more source

Effect of mechanical stresses on the domain structure of barium titanate single crystals

open access: yesРоссийский технологический журнал, 2020
This review article summarizes the material of years of research on the impact of mechanical stresses on the domain structure of multiaxhetoelectrics using the example of barium titanium monocrystals.
V. V. Borodina, S. O. Kramarov
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

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