Results 71 to 80 of about 15,594,346 (384)
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Influence of reference states on Jupiter’s dynamo simulations
Earth and Planetary Physics, 2021 Jupiter’s magnetic field is thought to be generated in its deep metallic hydrogen region through dynamo action, yet the detailed dynamic process remains poorly understood.
LongHui Yuan, YuFeng Lin, Chris A. Jones
doaj +1 more source
INTERNAL STRUCTURE OF ASTEROIDS HAVING SURFACE SHEDDING DUE TO ROTATIONAL INSTABILITY [PDF]
, 2015 Surface shedding of an asteroid is a failure mode where surface materials fly off due to strong centrifugal forces beyond the critical spin period, while the internal structure does not deform significantly. This paper proposes a possible structure of an
M. Hirabayashi +2 more
semanticscholar +1 more source
Unionization Structures in International Oligopoly [PDF]
LABOUR, 2012 Abstract. We examine how competition in international markets affects a union's choice of wage regime, which can be either uniform or discriminatory. Firms are heterogeneous with regard to international competition. When unions choose their wage regimes sequentially, a discriminatory outcome becomes more likely when international competition increases.
Pagel, Beatrice, Wey, Christian
openaire +3 more sources
Molecular Oncology, EarlyView.The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld +7 more
wiley +1 more source
Frontiers in Earth Science, 2022 Structural deformation has a very important effect on the particle size and adsorption/desorption properties of coal, which is widely distributed in China, but there are few studies in this area. The effects of particle size and internal structure on the
Xiaoshi Li +8 more
doaj +1 more source
Image Inpainting with External-internal Learning and Monochromic Bottleneck [PDF]
arXiv, 2021 Although recent inpainting approaches have demonstrated significant improvements with deep neural networks, they still suffer from artifacts such as blunt structures and abrupt colors when filling in the missing regions. To address these issues, we propose an external-internal inpainting scheme with a monochromic bottleneck that helps image inpainting ...
arxiv
Molecular Oncology, EarlyView.VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park +6 more
wiley +1 more source
Generation of mesostructure for lattice discrete particle model
Acta Polytechnica CTU Proceedings, 2022 A preliminary study of two approaches for the internal structure generation utilized in the lattice discrete particle models (LDPM) [1] is presented.
Jan Vozáb +4 more
doaj +1 more source