Results 171 to 180 of about 215,987 (257)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Antibody-induced internalization and degradation of PLA2R amplifies CD4⁺ T cell activation. [PDF]

Theranostics
Liu Y, Li Y, Zhou H, Yu J, Deng P, Xu W, Pan B, Zhang L, Zhou H, Zhang J, Liu X, Shi M, Dong X, Tong B, Bi E, Guo N, Hu Y.   +16 more
europepmc   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Biocompatibility of Nickel Ferrite Nanoparticles on Systemic and Testicular Cells. [PDF]

ACS Omega
Silva CCM, Viana PIM, Valverde TM, Ardisson JD, Fagundes DA, Costa GMJ.   +5 more
europepmc   +1 more source

The emerging complexity of PDGFRs: activation, internalization and signal attenuation

, 2020
Madison A. Rogers, Katherine A. Fantauzzo   +1 more
openalex   +2 more sources

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

ATP increases murine neuroblastoma cell size through a PANX1- and macropinocytosis-dependent mechanism. [PDF]

Biol Open
Boyce AKJ, You H, Wicki-Stordeur LE, Swayne LA.   +3 more
europepmc   +1 more source

Alternative Mechanism Behind Low-density Lipoprotein Internalization in Endothelial Cells

, 2015
Kristin Chu
openalex   +1 more source

Gamma Interferon Enhances Internalization and Early Nonoxidative Killing ofSalmonella entericaSerovar Typhimurium by Human Macrophages and Modifies Cytokine Responses

, 2005
Melita A. Gordon, Dominic Jack, David H. Dockrell, Margaret E. Lee, Robert C. Read   +4 more
openalex   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source