Results 161 to 170 of about 2,159,290 (329)

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

open access: yesAdvanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen   +7 more
wiley   +1 more source

International Cooperation to Resolve International Pollution Problems [PDF]

open access: yes
This article provides a non-technical overview of important results of the game theoretical literature on the formation and stability of international environmental agreements (IEAs) on transboundary pollution control. It starts out by sketching features
Micheal Finus
core  

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

open access: yesAdvanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang   +14 more
wiley   +1 more source

Orthopaedic Disorders in Cerebral Palsy in International Cooperation Projects: A Descriptive Cross-Sectional Study. [PDF]

open access: yesInt J Environ Res Public Health, 2021
Garrido-Ardila EM   +5 more
europepmc   +1 more source

Does the fight against corruption require international cooperation? [PDF]

open access: yes
This paper explores the role of corruption in a two-country model with fiscal spillovers. In the absence of cooperation on governance issues, countries always have a strategic incentive to appoint policymakers whose aversion to corruption is lower than ...
Pierre-Henri Faure
core  

Hot Electron‐Assisted Noble‐Metal‐Free Synergistic Photothermal Catalyst for Solar‐Driven Wastewater Remediation and Microbial Disinfection

open access: yesAdvanced Science, EarlyView.
A multifunctional Bi2Te3@CdS hybrid system is presented for solar‐driven wastewater remediation and indoor disinfection. The catalyst coated on PU foam efficiently harvests visible‐NIR light to generate heat and reactive oxygen species, enabling the rapid mineralization of organic pollutants.
Manish Kumar Sharma   +10 more
wiley   +1 more source

COVID-19 in Central Asia: Uzbekistan's new approach to international cooperation. [PDF]

open access: yesLancet Reg Health Eur, 2021
Shadmanov A   +4 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy