Results 71 to 80 of about 2,192,184 (309)
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen +6 more
wiley +1 more source
International Trade under Crisis Constraints [PDF]
Theoretical and Applied Economics, 2010 Competitiveness of the world nations is due to the trade liaisons between these nations and proves how the economies manage the present, in the crisis conditions, but merely, their future.
Alexandru TRIFU
doaj +1 more source
Hamlet’s crisis of meaning, mental wellbeing and meaninglessness in the War on Terror [PDF]
, 2008 Drawing on Shakespeare, and in particular Hamlet's psychological crisis, this paper examines the relationship between emotions and meaning, a key theme in artistic work, but, it is argued, neglected in social psychology.
Pupavac, Vanessa
core +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Evaluation of the vulnerability of components of the water supply system [PDF]
مهندسی و مدیریت ساخت, 2017 Water infrastructure is a vital vital artery that has always been exposed to natural and man-made threats over the years. This infrastructure is difficult for many people, since it is the center of gravity of a country, it is difficult to imagine life ...
Sare Roudbari +2 more
doaj
Foreign experience of public administration in the context of the economic equilibrium of synthetic economic crisis [PDF]
, 2017 This article identify catalysts of synthetic economic crisis. These catalysts are the subject of transnational corporations, international financial, trade organizations, regional integration groupings.
A. Gladchenko, S. Sardak, V. Dzhyndzhoian +1 more
core
Crisi Internazionale E Crisi Nazionale (National and International Crises)
SSRN Electronic Journal, 2012 L'articolo considera la situazione dell'Italia sulla scia della crisi finanziaria ed economica internazionale.Si sottolinea in particolare che l'Italia era già in una posizione critica prima del 2007-2008, principalmente a causa dell'insufficiente crescita economica.Il motivo principale delle basse performance del paese è individuato nell'insufficiente
openaire +2 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source