Results 71 to 80 of about 3,242,317 (303)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Institutional Change and Compliance in Forest Landscape Restoration Governance: Insights from the Western Highlands of Cameroon

Journal of Land Use Science
The debate regarding whether, in sub-Saharan Africa, exogenous1 and endogenous institutions2 have witnessed significant changes to facilitate contemporary Forest Landscape Restoration (FLR) processes remains inconclusive.
Raphael Owusu, Jude Ndzifon Kimengsi, Lukas Giessen   +2 more
doaj   +1 more source

Going Beyond the "Normative vs. Social" Standard: A Preliminary Framework for Evaluating the Legitimacy of International Institutions. [PDF]

Society, 2023
Liu P, Cao YH.
europepmc   +1 more source

International accounting standards (IAS): implications for financial institutions [PDF]

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Seeger, Norbert
core  

The Talloires Network and the MacJannet Prize for Global Citizenship: Explorations on sustainable and innovative leadership [PDF]

, 2017
Higher education does not exist in a vacuum. Institutions of higher learning should serve as vibrant and dynamic anchors to their communities and to society.
Ching, Monique, Hernandez Cavalcanti, Brianda   +1 more
core   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Analysis of antibiotic use, biosecurity and mortality in semi-intensive broiler farms in Kenya

BMC Veterinary Research
The indiscriminate use of antibiotics in food-producing animals contributes to antimicrobial resistance (AMR), posing a global threat. Understanding the factors associated with antibiotic use is critical to combat resistance while maintaining animal ...
Naomi P. Kemunto, Dishon M. Muloi, Eugine L. Ibayi, Jane K. Njaramba, Vivian Hoffmann, Mike Murphy, Søren S. Nielsen, Arshnee Moodley   +7 more
doaj   +1 more source

The Global Health Architecture: Governance and International Institutions to Advance Population Health Worldwide. [PDF]

Milbank Q, 2023
Gostin LO, Friedman EA, Finch A.
europepmc   +1 more source

Institutions, Information, and Trade Policy in Times of Crisis [PDF]

, 2011
The paper examines the role of international institutions in preventing the rise of protectionism in times of times of crisis. Economic crisis exacerbates uncertainty in the conduct of commercial relations and thus makes it more likely for countries to ...
Baccini, Leonardo, Kim, Soo Yeon
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source