Results 221 to 230 of about 1,034,736 (266)

Effect of Lepirudin on the International Normalized Ratio

Annals of Pharmacotherapy, 2005
BACKGROUND: Many patients receiving direct thrombin inhibitor (DTI) therapy require transition to warfarin. This transition may be complicated by DTI-induced elevations in the international normalized ratio (INR). While the effect of argatroban on the INR has been characterized, data assessing the effect of lepirudin on the INR are limited.
Joan C. Mattson, Maureen A. Smythe, John M Koerber, Jennifer L. Stephens   +3 more
openaire   +3 more sources

Drug interactions between tyrosine kinase inhibitors (gefitinib and erlotinib) and warfarin: Assessment of international normalized ratio elevation characteristics and in vitro CYP2C9 activity

Journal of Oncology Pharmacy Practice, 2018
Background Elevation of the international normalized ratio and bleeding complications has been reported in patients taking warfarin concomitantly with tyrosine kinase inhibitors such as gefitinib and erlotinib.
M. Hiraide, Y. Minowa, Y. Nakano, Kenichi Suzuki, T. Shiga, M. Nishio, Junya Miyoshi, Harumi Takahashi, T. Hama   +8 more
semanticscholar   +1 more source

Relationship between International Normalized Ratio and Outcomes in Modern Trials with Warfarin Controls

Pharmacotherapy, 2018
A target international normalized ratio (INR) of 2–3 has been recommended for patients with atrial fibrillation (AF) and risk factors for thromboembolism. This recommendation is largely based on evidence from observational studies a decade ago.
T. McDowell, J. Lawrence, J. Florian, M. Southworth, Stephen Grant, N. Stockbridge   +5 more
semanticscholar   +1 more source

International Normalized Ratio: Towards Improved Accuracy

Thrombosis and Haemostasis, 1999
Oral anticoagulants such as warfarin, acenocoumarin, and phenprocoumon induce depletion of vitamin K-dependent coagulation factors, causing prolongation of the prothrombin time (PT) and the International Normalized Ratio (INR). Commercially available thromboplastin reagents used for the determination of the PT vary in their response to coagulation ...
openaire   +3 more sources

International normalized ratio in anticoagulant therapy: understanding the issues

International Journal of Trauma Nursing, 1997
Recently, a change in anticoagulation therapy occurred that is still partially ignored by the healthcare community. Understanding the controversy over the use of the internal normalized ratio in monitoring patients receiving warfarin therapy is important for nurses who provide care to these patients.
AL Severson, LR Baldwin, TG DeLoughery
openaire   +4 more sources

Prothrombin Time/International Normalized Ratio

2013
Prothrombin time (PT) and/or International Normalized Ratio (INR) is the most commonly used coagulation assay in health care, to diagnose the risk of bleeding and to monitor oral anticoagulation therapy. This test is based on the principle that in citrated plasma, the addition of a thromboplastin and CaCl2 allows for formation of a stable clot.
openaire   +3 more sources

Assessing Random Error in the International Normalized Ratio

Therapeutic Drug Monitoring, 1994
Changes in the international normalized ratio (INR) following warfarin administration may be explained not only by the attendant anticoagulant effect but also, in part, by random errors normally associated with laboratory assays. Thus, a patient's true INR will differ from the reported value by some random error related to the variability in the ...
openaire   +3 more sources

Management of Anticoagulation Therapy With the International Normalized Ratio

Journal of the American Academy of Nurse Practitioners, 1996
Nurse practitioners have both the education and the counseling skills to evaluate and manage patients receiving warfarin therapy. The benefits of such treatment should be weighed against potential risk before initiation of therapy. Patients receiving warfarin need to be closely monitored because of the narrow therapeutic range of the drug.
openaire   +3 more sources

Warfarin and the International Normalized Ratio: Reducing Interlaboratory Effects

DICP, 1991
In North America, the dose of warfarin has been unintentionally increased during the past two decades because of failure to recognize the effect on the anticoagulation test of less sensitive tissue thromboplastins. Although there still is some controversy, the suggested dose of warfarin has now been adjusted downward to reduce the risk of bleeding ...
Dennis F. Thompson, Gordon J. Vanscoy, John R. Krause, Marsha A. Raebel   +3 more
openaire   +3 more sources

False prolongation of International Normalized Ratio associated with daptomycin

American Journal of Health-System Pharmacy, 2018
Persistent elevation of prothrombin time (PT) and International Normalized Ratio (INR) values in a patient receiving daptomycin is reported.A morbidly obese 51-year-old man was hospitalized for evaluation for surgical intervention for gallstone pancreatitis and biliary obstruction.
Kelli Rumbaugh, Susan E. Smith
openaire   +3 more sources