Results 41 to 50 of about 262,567 (294)

International Normalized Ratio determination using calibrated reference plasmas [PDF]

British Journal of Haematology, 1997
We have compared the conventional method of International Normalized Ratio (INR) determination with an alternative method involving extrapolation from a calibration curve using freeze‐dried ‘reference’ plasmas. The latter approach does not require the determination of a mean normal prothrombin time (MNPT) or local system International Sensitivity Index
A R, Hubbard, S M, Margetts, T W, Barrowcliffe   +2 more
openaire   +2 more sources

Knowledge of warfarin therapy among patients attending Warfarin Clinic at a Public Hospital in Northern part of Malaysian Peninsular

Archives of Pharmacy Practice, 2016
Background: Patient′s knowledge of anticoagulation therapy is important to achieving and maintaining optimal therapy outcome as well as reducing adverse events.
Teoh Boon Ching, Syed Azhar Syed Sulaiman, Amal K Suleiman, Syed Wasif Gillani, Usman Abubakar   +4 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Elevated international normalized ratio with the consumption of grapefruit and use of warfarin

SAGE Open Medical Case Reports, 2013
A 65-year-old male with documented atrial flutter who was taking warfarin chronically returned to the anticoagulation clinic for follow-up, after having been on 10 mg daily for approximately 2 weeks.
Andrew B Bodiford, Fred O Kessler, Joli D Fermo, Kelly R Ragucci   +3 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

In Potential Stroke Patients on Warfarin, the International Normalized Ratio Predicts Ischemia

Cerebrovascular Diseases Extra, 2017
Background: Stroke can occur in patients on warfarin despite anticoagulation. Patients with a low international normalized ratio (INR) should theoretically be at greater risk for ischemia than those who are therapeutic.
Cathy Cao, Ashley Martinelli, Brian Spoelhof, Rafael H. Llinas, Elisabeth B. Marsh   +4 more
doaj   +1 more source

Intrahospital Correlation of the International Normalized Ratio

Clinical and Applied Thrombosis/Hemostasis, 2008
Background. Monitoring of oral anticoagulant therapy (OAT) is usually accomplished by measuring prothrombin time and the international normalized ratio (INR). However, thromboplastins have different responsiveness and sensitivity to vitamin K—dependent coagulation factors depletion.
Alejandro, Lazo-Langner, Rosario, Villa-Márquez, Darinel, Hernández-Hernández, Sonia, Rojas-Maya, Josefa, Piedras   +4 more
openaire   +2 more sources

Does International Normalized Ratio Level Predict Pulmonary Embolism? [PDF]

Clinical Orthopaedics & Related Research, 2012
Preventing pulmonary embolism is a priority after major musculoskeletal surgery. The literature contains discrepant data regarding the influence of anticoagulation on the incidence of pulmonary embolism after joint arthroplasty. The American College of Chest Physicians guidelines recommend administration of oral anticoagulants (warfarin), aiming for an
Hansen, Patricia, Zmistowski, Benjamin, Restrepo, Camilo, Parvizi, Javad, Rothman, Richard H   +4 more
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Correlation of prehospital point-of-care international normalized ratio to laboratory-based international normalized ratio in acute traumatic coagulopathy

Journal of Trauma and Acute Care Surgery, 2022
Acute traumatic coagulopathy (ATC) is associated with increased mortality and hospital transfusion requirements.1,2 Accurate prehospital identification of ATC may improve outcomes by expediting care. Unlike clinical scores, which may include subjective components,3 point-of-care (POC) international normalized ratio (INR) testing provides an objective ...
Bodnar, Daniel, Parker, Lachlan, Meister, Matthew, Ryan, Glenn, Rashford, Stephen, Wullschleger, Martin, Lam, Alfred K, Bosley, Emma   +7 more
openaire   +3 more sources