Results 131 to 140 of about 18,854,124 (268)

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Whole blood viscosity assessment issues III: Association with international normalized ratio and thrombocytopenia

, 2010
Background: Anticoagulant and antiplatelet therapies are being used interchangeably or in combination. While international normalized ratio is assessed to determine anticoagulant’s contraindication/need, whole blood viscosity is not assessed to determine
Nwose, Ezekiel Uba, Cann, Nathan, Butkowski, Eugene   +2 more
core  

Discordance Between Japanese and European Definitions of Acute‐on‐Chronic Liver Failure in Alcohol‐Related Cirrhosis: Insights From a 10‐Year Consecutive Cohort

Hepatology Research, EarlyView.
Substantial discordance was observed between Japanese and EASL‐CLIF definitions of acute‐on‐chronic liver failure in alcohol‐related cirrhosis. Many Japanese‐defined cases were classified as EASL‐CLIF grade 0 yet retained non‐negligible 1‐year mortality, highlighting the complementary roles of hepatic‐based and organ failure–based frameworks.
Hidehiro Kamezaki, Nana Yamada, Terunao Iwanaga, Takafumi Sakuma, Koji Takahashi, Junichi Senoo, Makoto Arai, Tatsuo Kanda, Sadahisa Ogasawara, Jun Kato   +9 more
wiley   +1 more source

Cisterna Chyli Dilation Is a Risk Factor for Liver Nodules and Hepatocellular Carcinoma in Fontan‐Associated Liver Disease: Pathophysiological Role of Lymphatic Dysfunction

Hepatology Research, EarlyView.
ABSTRACT Aim In Fontan‐associated liver disease (FALD), chronic congestion often confounds conventional fibrosis markers, complicating surveillance for hepatocellular carcinoma (HCC). Although lymphatic dysfunction is fundamental to Fontan physiology, its contribution to hepatocarcinogenesis remains unclear.
Koji Imoto, Masatake Tanaka, Takeshi Goya, Yuuki Azuma, Tomonobu Hioki, Yusuke Morita, Keisuke Sakaguchi, Nobuhiro Fujita, Takamori Kakino, Ayako Ishikita, Kenichiro Yamamura, Ichiro Sakamoto, Kousei Ishigami, Kohtaro Abe, Yoshihiro Ogawa   +14 more
wiley   +1 more source

Novel Prognostic Model to Predict In-Hospital Mortality in Patients with Liver Cirrhosis

Acta Medica Indonesiana
Background: Liver cirrhosis remains a major global health concern associated with high in-hospital mortality, especially in Southeast Asia. Existing prognostic scores, such as Child-Pugh and albumin-bilirubin scores, exhibit variable accuracy ...
Hendra Raharja, Taufik Sungkar, Ilhamd Ilhamd   +2 more
doaj   +4 more sources

Warfarin overdose successfully treated using prophylactic vitamin K infusion without severe coagulopathy: A case report

Acute Medicine & Surgery
Background Warfarin, a vitamin K antagonist, is widely used for preventing and treating thromboembolic diseases. While guidelines exist for managing elevated prothrombin time‐international normalized ratio (INR) in patients on warfarin, the treatment for
Ryosuke Omoto, Yutaka Umemura, Yuki Kokubu, Takeyuki Kiguchi, Satoshi Fujimi   +4 more
doaj   +1 more source

Do We Really Know How to Manage Anticoagulated Patients for Periodontal Nonsurgical Therapy? An Observational Cohort Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objectives The aim of this work is to assess and compare the impact of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKA) during and immediately after periodontal nonsurgical therapy. Materials and Methods A prospective observational cohort study was conducted with patients who presented a history of cardiovascular disease ...
F. Berton, A. Rapani, F. Costantinides, V. Nicolin, D. Cuhureanu, R. Di Lenarda   +5 more
wiley   +1 more source

Reducing the determination errors of the international normalized ratio by using plasma cogulation calibrators

, 2019
The objective was to use of a minimum number of ISI (International Sensitivity Index) to determine the International Normalized Ratio (INR). This specific calibration methods allowed to calculate ISI for all other thromboplastines comparative with the ...
Ciobanu, Corina-Paraschiva, Gavăt, Cristian-Cătălin, Mărculescu, Afrodita-Doina, Kamel, Earar, Vasilescu, Leonard-Vasile   +4 more
core   +1 more source

Assessment of Thrombin Generation in Pediatric Patients on Extracorporeal Life Support: Impact of Bivalirudin and Other Anticoagulants

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Bivalirudin is an alternative anticoagulant to heparin and is widely used in pediatric extracorporeal life support (ECLS). Its activity is monitored using activated partial thromboplastin time (aPTT) and/or more specific tests such as plasma‐diluted thrombin time (dTT).
Vadim Kostousov, Karen Bruzdoski, Amir Navaei, Jun Teruya   +3 more
wiley   +1 more source

Role of FibroScan in evaluating hepatic involvement in systemic amyloidosis: a single‐centre prospective pilot study

Internal Medicine Journal, EarlyView.
Abstract Background Amyloidosis encompasses a group of diseases characterised by extracellular deposition of misfolded protein fibrils, potentially leading to organ dysfunction. Liver involvement occurs via direct amyloid infiltration, common in immunoglobulin light chain (AL) amyloidosis, or congestive hepatopathy, more typical in transthyretin (ATTR)
M Tang, N Vootukuru, J Tjahyadi, D Clayton Chubb, H Jina, SB Ting, S Bloom, R Sawhney, S Gibbs, O. Niewiadomski   +9 more
wiley   +1 more source