Results 81 to 90 of about 56,745 (303)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Pacifism in Fin-de-Siècle Austria: The Politics and Limits of Peace Activism [PDF]

, 2014
The late Habsburg Monarchy produced two of the most renowned peace activists of their day: Bertha von Suttner and Alfred Fried. In comparison to these two Nobel Peace laureates, the main association of Austro-pacifism – the Österreichische ...
Adler, Adler, Allmayer-Beck, Angell, Bader-Zaar, Beller, Berghahn, Bernstein, Best, Bloch, Bonn, Boyer, Bruckmüller, Ceadel, Charmatz, Chickering, Cooper, DANIEL LAQUA, de Marcoartu, Deák's, Dülffer, Evans, Fischhof, Freiherr von Walterskirchen, Fried, Fried, Fried, Fried, Fried, Fried, Förster, Gilman, Glettler, Godsey, Goldscheid, Goldscheid, Göhring, Hamann, Hamann, Hanák, Havránek, Holl, Holl, Howard, Höbelt, Höbelt, Höbelt, Janik, Judson, Judson, Kann, Katscher, Katscher, Kempf, Kirchhoff, Kobatsch, Kovács, Kowalek, Kreuzig, Lackey, Laity, Laqua, Laurence, Lawrence, Leitsch-Prost, Liebknecht, Lyons, Løvland, Mazower, Müller, Novikov, Okey, Plöhn, Rothenberg, Schorske, Schönemann-Behrens, Stargardt, Stekel, Suttner, Suttner, Türr, Uhlig, Unowsky, Unowsky, Ustor, van den Dungen, Vermes, von Plener, von Plener, von Suttner, von Suttner, von Suttner, von Suttner, von Suttner, Walz, Wank, Wank, Wette, Whiteside   +98 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

La Guerre des sables de 1963

Études Caribéennes
This article revisits the 1963 “War of the Sands” and examines Cuba’s decisive role in providing military support to newly independent Algeria. Drawing on diplomatic archives, press sources and political testimonies, it argues that the Cuban intervention 
Salim Lamrani
doaj   +1 more source

Beyond Christian Nationalism: How the American Committee on Religious Rights and Minorities Made Religious Pluralism a Global Cause in the Interwar Era

Religions, 2016
During the 1920s and 1930s, the American Committee on Religious Rights and Minorities offered a potent challenge to the view of the United States as a Christian nation.
David Mislin
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

La primera brigada médica cubana en Argelia en 1963

Études Caribéennes
This article analyses the deployment, in 1963, of the first Cuban medical brigade to Algeria as a foundational moment in South–South cooperation during the early years of Algerian independence.
Salim Lamrani
doaj   +1 more source

The LIOn's share: How the Liberal International Order Contributes to its Own Legitimacy Crisis. Harvard CES Open Forum Series2019-2020 [PDF]

, 2020
The liberal international order (LIO) is experiencing a legitimacy crisis in its Western heartland. What causes this crisis? Existing approaches focus on the LIO’s unequal allocation of wealth and values that produces losers and thus breeds ...
Kreuder-Sonnen, Christian, Rittberger, Berthold   +1 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source