Results 201 to 210 of about 851,505 (288)

Effects of a Community-Based Multi-Component Intervention on Subjective Well-Being in Older Adults: The Chofu-Digital-Choju Project in Japan. [PDF]

Geriatrics (Basel)
Nakada T, Kurotani K, Seino S, Kozawa T, Murota S, Eto M, Shimasawa J, Shimizu Y, Tsurugano S, Katsukawa F, Sakamoto K, Washizaki H, Ishigaki Y, Sakamoto M, Takadama K, Yanai K, Matsuo O, Kameue C, Suzuki H, Ohkawara K.   +19 more
europepmc   +1 more source

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

Advanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka, Richard T. Osgood, Hidetomi Nitta, Artur A. Indzhykulian   +3 more
wiley   +1 more source

Coordination of Cyanobacterial Nitrate Assimilation and Photosynthesis by a Novel PsbO‐Interacting Protein PirN

Advanced Science, EarlyView.
PirN was identified as a previously uncharacterized PsbO‐interacting protein specifically induced in nitrate‐grown cyanobacteria. Loss of PirN leads to coordinated downregulation of PsbO and the nitrate reductase NarB, causing decreased PSII activity and impaired growth under nitrate conditions. Complementation with either PsbO or NarB largely restores
Chengcheng Huang, Zhen Xiao, Haitao Ge, Gaojie Wang, Jinghui Dong, Yan Wang, Hang Yang, Xing Wang, Hui Gao, Zhongshu Wang, Huanling Yang, Yuanya Zhang, Xiahe Huang, Wu Xu, Weimin Ma, Wenqiang Yang, Yingchun Wang   +16 more
wiley   +1 more source

Exploring the Cognitive and Behavioral Risks and Maintenance Factors of Hikikomori: Protocol for an Ecological Momentary Assessment Study.

JMIR Res Protoc
MacLellan A, Takano K.
europepmc   +1 more source

Effectiveness of a CDSS and Internet of Things-based comprehensive hypertension management system in primary health care settings: study protocol for the CATCH Trial. [PDF]

Trials
Li B, Peng K, Xu K, Liu X, Lu C, Shi Y, Han G, Wang L, Chen X, Ning Z, Li Y.   +10 more
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Initial Insights Into an Institutional Secure Large Language Model for Magnetic Resonance Imaging Examination Requests: Retrospective Study.

J Med Internet Res
Hallinan JTPD, Leow NW, Low YX, Lee A, Ong W, Chan MDZ, Devi GK, He SS, Loh DD, Lim DSW, Low XZ, Lim MC, Yong C, Sng WJ, Teo EC, Tan JH, Kumar N, Makmur A, Ting Y.   +18 more
europepmc   +1 more source

Impact of sensory processing difficulties on academic performance and occupational balance in university students (PREstEO): Protocol for a cross-sectional and longitudinal study. [PDF]

PLoS One
Prieto-Botella D, Peral-Gómez P, Sánchez-Pérez A, Gándara-Gafo B, Couço-Lucas C, Fernandes P, Serrada-Tejeda S, Lloret D, Fernández-Pires P.   +8 more
europepmc   +1 more source

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Study Protocol: It is time to dig deeper: A cross-country implementation mapping study of the iFightDepression® (online self-management) tool. [PDF]

PLoS One
Rotter T, Petrovic M, Zarzycki M, Allenhof C, Schnitzspahn K, Toczyski P, Justicia A, Leal SA, Chan J, Leimhofer J, Scholze K, Hackel S, Sola VP, Hegerl U.   +13 more
europepmc   +1 more source