Results 61 to 70 of about 13,291 (315)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Progressive Iterative Approximation of Non-Uniform Cubic B-Spline Curves and Surfaces via Successive Over-Relaxation Iteration

Mathematics, 2022
Geometric iteration (GI) is one of the most efficient curve- or surface-fitting techniques in recent years, which is famous for its remarkable geometric significance. In essence, GI can be thought of as the sum of iterative methods for solving systems of
Huahao Shou, Liangchen Hu, Shiaofen Fang
doaj   +1 more source

Stability of Fredholm properties on interpolation Banach spaces

, 2020
The main aim of this paper is to prove novel results on stability of the semi-Fredholm property of operators on interpolation spaces generated by interpolation functors. The methods are based on some general ideas we develop in the paper.
Kruglyak, Natan,, Asekritova, Irina,, Mastylo, M.,   +2 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Generalized weighted Sobolev spaces and applications to Sobolev orthogonal polynomials, I [PDF]

, 2004
36 pages, no figures.-- MSC2000 codes: 41A10, 46E35, 46G10.-- Part II of this paper published in: Approx. Theory Appl. 18(2): 1-32 (2002), available at: http://e-archivo.uc3m.es/handle/10016/6483MR#: MR2047389 (2005k:42062)Zbl#: Zbl 1081.42024In this ...
Pestana, Domingo, Romera, Elena, Rodríguez, José M., Álvarez, Venancio   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Finite element quasi-interpolation and best approximation [PDF]

, 2015
This paper introduces a quasi-interpolation operator for scalar- and vector-valued finite element spaces constructed on affine, shape-regular meshes with some continuity across mesh interfaces.This operator gives optimal estimates of the best ...
A. Ern, J. Guermond
semanticscholar   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Approximation in Perceptual Completion

Gestalt Theory
Normally, the perception of complete visual shapes given incomplete sensory evidence can be explained by interpolation; i.e., by the smooth monotonic connection of literally represented contour stimuli.
Gerbino Walter
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source