Results 161 to 170 of about 2,751,488 (247)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Evaluating the Accuracy and Diagnostic Reasoning of Multimodal Large Language Models in Interpreting Neuroradiology Cases From <i>RadioGraphics</i>. [PDF]

Korean J Radiol
Suh PS, Ko JS, Shim WH, Heo H, Woo CY, Park H, Suh CH.   +6 more
europepmc   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Visual recognition limitations in multimodal large language models: A comparative analysis of histological image interpretation. [PDF]

PLOS Digit Health
Mavrych V, Yousef EM, Yaqinuddin A, Shaikh AA, Bolgova O.   +4 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Archéologie des images et logique rétrospective

Images Re-Vues, 2013
Andrea Pinotti
doaj   +1 more source

A bedside staffing model with perfusionists for pediatric extracorporeal membrane oxygenation (ECMO) at a high-volume center★. [PDF]

J Extra Corpor Technol
Nemeh C, Cain-Trivette C, Schmoke N, Varner C, Brewer M, Clark E, Ream H, Vargas Chaves D, Choudhury T, Stylianos S, Middlesworth W, Cheung EW.   +11 more
europepmc   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Diagnostic Yield of Comprehensive Reanalysis After Nondiagnostic Short-Read Genome Sequencing in Infants With Unexplained Epilepsy. [PDF]

Neurology
Nguyen JNH, Lachgar-Ruiz M, Higginbotham EJ, Coleman M, Coleman J, Shao W, Scotchman E, Pritchard AJ, Bell KM, Chitty LS, Christodoulou J, De Fazio P, Deshwar AR, Eltze C, Griffiths AJS, Hassell J, Jain P, Kaliakatsos M, Liang NSY, Lombard P, Marshall CR, Marx C, McRae L, Mulhern S, Paternoster B, Perez Caballero A, Pipko N, Sidhu J, Smith L, Stark Z, Trost B, Wakeling E, White SM, Yoong M, Gene-STEPS Study Group, IPCHiP Executive Committee,, Chandler NJ, Cross JH, Scheffer IE, Chau V, Poduri A, Howell KB, Stephenson SEM, McTague A, Costain G, D'Gama AM.   +45 more
europepmc   +1 more source