Results 61 to 70 of about 2,751,409 (242)
MIMes and MeRMAids: On the Possibility of Computer-aided Interpretation
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Geoffrey Rockwell
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Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Sur une interprétation du marxisme
Lhomme Jean. Sur une interprétation du marxisme. In: Revue économique, volume 1, n°1, 1950. pp.
Lhomme, Jean
core +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Sur une interprétation du marxisme
Lefebvre Henri. Sur une interprétation du marxisme. In: L'Homme et la société, N. 4, 1967. pp.
Lefebvre, Henri
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
إشكالية ترجمة الشعر: محمود درويش نموذجا
Mahmoud Darwich est probablement l'un des auteurs les plus difficiles à aborder, peut-être parce qu'il s’agit d'un personnage complexe. Poète politique ? Poète de la résistance ? Poète de l'exile ?
صبرينة دندان
doaj
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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Interprétation de la loi et perversion du droit
Cet article vise à contribuer à la réception des analyses de Bernd Rüthers en France. Depuis trente ans, cet historien du droit a profondément renouvelé l’étude de la crise du droit sous le national-socialisme en mettant en évidence un élément crucial ...
Christian Roques
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