Results 61 to 70 of about 2,751,409 (242)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Sur une interprétation du marxisme

open access: yes, 1950
Lhomme Jean. Sur une interprétation du marxisme. In: Revue économique, volume 1, n°1, 1950. pp.
Lhomme, Jean
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Sur une interprétation du marxisme

open access: yes, 1967
Lefebvre Henri. Sur une interprétation du marxisme. In: L'Homme et la société, N. 4, 1967. pp.
Lefebvre, Henri
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

إشكالية ترجمة الشعر: محمود درويش نموذجا

open access: yesTraduction et Langues, 2007
Mahmoud Darwich est probablement l'un des auteurs les plus difficiles à aborder, peut-être parce qu'il s’agit d'un personnage complexe. Poète politique ? Poète de la résistance ? Poète de l'exile ?
صبرينة دندان
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Interprétation de la loi et perversion du droit

open access: yesAstérion, 2006
Cet article vise à contribuer à la réception des analyses de Bernd Rüthers en France. Depuis trente ans, cet historien du droit a profondément renouvelé l’étude de la crise du droit sous le national-socialisme en mettant en évidence un élément crucial ...
Christian Roques
doaj   +1 more source

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