Results 81 to 90 of about 424,586 (329)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Interpretations of Linear Orderings in Presburger Arithmetic [PDF]

arXiv, 2019
Presburger Arithmetic $\mathop{\mathbf{PrA}}\nolimits$ is the true theory of natural numbers with addition. We consider linear orderings interpretable in Presburger Arithmetic and establish various necessary and sufficient conditions for interpretability depending on dimension $n$ of interpretation.
arxiv  

Implicit Mixture of Interpretable Experts for Global and Local Interpretability [PDF]

arXiv, 2022
We investigate the feasibility of using mixtures of interpretable experts (MoIE) to build interpretable image classifiers on MNIST10. MoIE uses a black-box router to assign each input to one of many inherently interpretable experts, thereby providing insight into why a particular classification decision was made.
arxiv  

Re-interpreting rules interpretability

International Journal of Data Science and Analytics, 2022
AbstractTrustworthy machine learning requires a high level of interpretability of machine learning models, yet many models are inherently black-boxes. Training interpretable models instead—or using them to mimic the black-box model—seems like a viable solution.
Linara Adilova, Michael Kamp, Gennady Andrienko, Natalia Andrienko   +3 more
openaire   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

The Nine Lives of Schroedinger's Cat [PDF]

arXiv, 1995
This MSc dissertation surveys nine interpretations of non-relativistic quantum mechanics. Extensive references are given. The interpretations covered are: the orthodox interpretation, Bohr's interpretation, the idea that the mind causes collapse, hidden variables, the many-worlds interpretation, the many-minds interpretation, Bohm's interpretation and ...
arxiv  

Ensemble Interpretation: A Unified Method for Interpretable Machine Learning [PDF]

arXiv, 2023
To address the issues of stability and fidelity in interpretable learning, a novel interpretable methodology, ensemble interpretation, is presented in this paper which integrates multi-perspective explanation of various interpretation methods. On one hand, we define a unified paradigm to describe the common mechanism of different interpretation methods,
arxiv  

A review of general pain measurement tools and instruments for consideration of use in COPD clinical practice

International Journal of COPD, 2017
Alisha Maree Johnson,1 Sheree MS Smith1,2 1School of Nursing and Midwifery, Western Sydney University, Penrith, 2Respiratory, Sleep, and Environmental Health Research Academic Unit, Liverpool Hospital, Liverpool, NSW, Australia Background: The ...
Johnson AM, Smith SMS
doaj  

Bio-inspired Analysis of Deep Learning on Not-So-Big Data Using Data-Prototypes

Frontiers in Computational Neuroscience, 2019
Deep artificial neural networks are feed-forward architectures capable of very impressive performances in diverse domains. Indeed stacking multiple layers allows a hierarchical composition of local functions, providing efficient compact mappings ...
Thalita F. Drumond, Thierry Viéville, Frédéric Alexandre   +2 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source