Results 71 to 80 of about 601,707 (261)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Interpreting the Dimensions of Speaker Embedding Space

open access: yesCoRR
Speaker embeddings are widely used in speaker verification systems and other applications where it is useful to characterise the voice of a speaker with a fixed-length vector. These embeddings tend to be treated as "black box" encodings, and how they relate to conventional acoustic and phonetic dimensions of voices has not been widely studied.
openaire   +2 more sources

Interpretable visualizations of data spaces for classification problems

open access: yesMachine Learning: Science and Technology
Abstract How do classification models ‘see’ our data? Based on their success in delineating behaviors, there must be some lens through which it is easy to see the boundary between classes; however, our current set of visualization techniques makes this prospect difficult.
Christian Jorgensen   +3 more
openaire   +3 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Wikipedia information flow analysis reveals the scale-free architecture of the semantic space.

open access: yesPLoS ONE, 2011
In this paper we extract the topology of the semantic space in its encyclopedic acception, measuring the semantic flow between the different entries of the largest modern encyclopedia, Wikipedia, and thus creating a directed complex network of semantic ...
Adolfo Paolo Masucci   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

The Space of Connections as the Arena for (Quantum) Gravity

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2011
We review some properties of the space of connections as the natural arena for canonical (quantum) gravity, and compare to the case of the superspace of 3-metrics.
Steffen Gielen
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

The Challenges of Environmental Protection in Outer Space Following Russia’s Anti-Satellite (ASAT) Weapon Test Activities

open access: yesYustisia
One of the effects of space activities is the creation of space debris that can endanger either the space environment or the Earth’s environment. In response to concerns regarding a swift escalation in space debris, Russia tested its Anti-Satellite (ASAT)
Ribqha Claudya, Irawati Handayani
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

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