Results 71 to 80 of about 136,231 (263)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Lingue Culture Mediazioni, 2020 As a knowledge dissemination and popularization strategy, intratextual reformulation plays a significant role in explaining, defining and describing concepts in informative and explicatory texts.
Chiara Preite
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Forum: Qualitative Social Research, 2008 "Interpretative Sozialforschung. Eine Einführung" ["Interpretative social research: An Introduction"] by Gabriele ROSENTHAL introduces the methods of and background to interpretative social research.
Matthias Kötter
doaj
Motivating a volunteer workforce in the criminal justice system [PDF]
, 2014 The Optional Protocol to the Convention against Torture and Other Cruel, Inhuman or Degrading Treatment or Punishment (OPCAT) requires that police detention processes are monitored and inspected.
Eccles, Thomas B, Biggs, David M
core
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Archaeographic and conceptual advances in interpreting Iberian Neolithisation
Documenta Praehistorica, 2004 Prehistoric research has evolved, in the last decade, from a mere collaboration of disciplines into a new, trans-disciplinary, approach to Prehistoric contexts. New stable research teams, involving researchers with various scientific backgrounds (geology,
Luiz Oosterbeek
doaj +1 more source
, 2009 The Out-of-Body Experience (OBE) is an anomalous experience that has been found to occur under a variety of circumstances. This paper will take as its focus the in-depth examination of the lived experience of having an OBE as described by two novice ...
Wilde, D.J. +3 more
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source