Results 101 to 110 of about 1,924,262 (337)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Interpretative semiotics and the Criticism of Culture Systems

, 2020
   تحاول هذه الدراسة اﻹجابة عن بعض اﻹشكاﻻت لكل المهتمين بقضايا تحليل الخطاب؛ يتعلق اﻷمر بمفهوم السميائيات التأويلية، بوصفها استراتيجية تمتلك تسنينا فلسفيا يرى في النص مستودعا من اﻻحتماﻻت الدﻻلية التي تتوقف ضرورة عند نقطة دﻻلية محددة يفرضها بناء
بريمي, عبد الله, Berrimi, Abdellah   +1 more
core  

Teacher’s act according to the mediation of NTIC: Between planned and real work activity

Calidoscópio, 2015
This study investigates the teaching act in a context of technological and professional higher education by means of interpretative analysis of the language actions.
Sueli Correia Lemes Valezi, Elvira Lopes Nascimento   +1 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

New academics negotiating communities of practice: learning to swim with the big fish

, 2007
This is an Accepted Manuscript of an article published by Taylor & Francis in Teaching in Higher Education on 5 June 2008, available online: http://www.tandfonline.com/10.1080/13562510701191943.This paper explores the use of situated cognition theory to ...
Jawitz, Jeff
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The role of section 2(1) and (4) of the European Communities Act and section 3(1) of the Human Rights Act in the interpretation and application of primary legislation: impact on judicial attitudes to the traditional concept of parliamentary sovereignty

The main aim of this thesis is to examine, through an analysis of relevant case law, the way in which the courts interpret and apply primary legislation pursuant to the interpretative obligation contained in section 2(1) and (4) of the European ...
Okorodas, Anthony
core  

The 1988 Washington Administrative Procedure Act—An Introduction

, 1989
The Washington Legislature passed a new Administrative Procedure Act ( APA ) in the spring of 1988, effective July 1, 1989. The Article guides the reader through the new APA, discusses its connection to general principles of administrative law and the ...
Andersen, William R.
core