Results 81 to 90 of about 1,938,741 (297)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Acta Universitatis Lodziensis Folia Iuridica, 2019 The discussed Act introduced an institution of post-penal isolation into the Polish legal system. The scientific community widely criticised this regulation at the stage of the legislative process and assessed it as being hasty and ill-conceived.
Franciszek Jędras, Katarzyna Grabarczyk
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
International Journal of Qualitative Studies on Health & Well-Being, 2011 One way of furthering our understanding of suicidal behaviour is to examine people's attitudes towards it and how they conceive the act. The aim of this study was to understand how lay persons conceive the impact of suicide on others and how that ...
Birthe Knizek +3 more
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Estudios de Teoría Literaria, 2023 This article examines various censorship marks that TikTok’s users have made on their copies of Harry Potter to erase the name of its author. In contrast to institutional censorship, censorship found in Harry Potter arises from franchise's readers and ...
Isidora D. Raby
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Hegel y Aristóteles: Una lectura de Metafísica XII, 7,1072b 18-30
Tópicos, 2013 The author does a hegelian interpretation of Metaphysics XII, 7, 1072b 18-30, passage with which the Encyclopedia of the Philosophical Sciences concludes. Here are drawn the relations and similitudes that exist between Aristotle's Unmoved Mover and Hegel'
Luis Xavier López-Farjeat
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source