Results 61 to 70 of about 2,246,452 (303)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Labour & Law Issues, 2016 The introduction aims at giving an overview of the new article 4 of the Worker’s Statute (Law no. 300/1970), concerning the employer’s monitoring powers, as recently reformed by the latest Italian Labour Reform (the so called Jobs Act).In particular ...
Maria Teresa Carinci
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
ACT Road Safety Taxi Manual 2023
, 2023 Executive Summary- There is a substantial amount of research which indicates that taxis are involved in a large number of crashes every year. The general reasons for this are numerous.
Wishart, Darren, Weaver, Shelly
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A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Transcription as interpretative activity [PDF]
, 2015 The main theses: 1. Transcription of data (audio and visual) is a part of research practice subject to weak afterthought. 2. Transcription is an interpretative act, not the projection of data.
Bielecka-Prus, Joanna
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The Bharatiya Sakshya Bill, 2023: A New and Unimproved Evidence Act
, 2023 The secrecy in drafting the bill to replace the Evidence Act is reminiscent of colonial legislation by committee.
Ambasta, Kunal
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A “Potency-Act” Interpretation of Quantum Physics
Journal of Modern Physics, 2021 Some considerations are presented on the so called “ontological interpretations” of quantum physics, starting from a remark by Werner Heisenberg on the relation between the probabilistic character of quantum states and the Aristotelian notion of “potency”.
openaire +3 more sources
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
, 2002 This pamphlet describes the African Conservation Tillage Network (ACT), which is a non-profit organization dedicated to information networks and partnerships that support the adoption and adaptation of Conservation Agriculture in Africa. This publication
African Conservation Tillage Network (ACT)
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