Results 51 to 60 of about 1,924,262 (337)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Remote control of workers' activities under the "JobsAct" (art. 23 D.Lgs. 151/2015): ideas to a debate

Labour & Law Issues, 2016
The introduction aims at giving an overview of the new article 4 of the Worker’s Statute (Law no. 300/1970), concerning the employer’s monitoring powers, as recently reformed by the latest Italian Labour Reform (the so called Jobs Act).In particular ...
Maria Teresa Carinci
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Thinking different as an act of resistance: Reconceptualizing the German protests in the COVID-19 pandemic as an emergent counter-knowledge order

Discourse & Society
Massive anti-government protests erupted during the COVID-19 pandemic in Germany. The crisis activated a potential for resistance that has been simmering under the impositions of late-modern knowledge society.
Florian Primig
semanticscholar   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

What are the experiences of those attending a self help hearing voices group: an interpretative phenomenological approach [PDF]

, 2011
Introduction: Self-help Hearing Voices Groups (HVG) have grown in popularity here in the UK, and internationally, since the 1980s. Despite research into the potential benefits of attending self-help groups for other mental health problems, little is ...
Hendry, Gemma Louise
core  

A BIOSEMIOTIC APPROACH TO THE QUESTION OF MEANING

Zygon, 2010
A sign is something that refers to something else. Signs, whether of natural or cultural origin, act by provoking a receptive system, human or nonhuman, to form an interpretant (a movement or a brain activity) that somehow relates the system to this ...
doaj   +2 more sources

Intentionality and the Perceptual World. Husserl, Schapp, and Blaustein on the Content of Sensations [PDF]

Phainomena
In the article, I investigate the role of sensation in the manifestation of the world in perceptual experience, as conceptualized through three distinct phenomenological approaches: those of Edmund Husserl, Wilhelm Schapp, and Leopold Blaustein.
Daniele Nuccilli
doaj   +1 more source