Results 51 to 60 of about 2,246,452 (303)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

The 1988 Washington Administrative Procedure Act—An Introduction [PDF]

open access: yes, 1989
The Washington Legislature passed a new Administrative Procedure Act ( APA ) in the spring of 1988, effective July 1, 1989. The Article guides the reader through the new APA, discusses its connection to general principles of administrative law and the ...
Andersen, William R.
core  

CONSTITUCIÓN Y LEY INTERPRETATIVA: ALGUNAS NOTAS SOBRE UNA PARADOJA Y PELIGROS RELATIVOS A ESTE TIPO DE LEY CONSTITUTION AND STATUTE INTERPRETATIVE: SOME NOTES CONCERNING AND PARADOX AND DANGERS RELATIVE TO BE STATUTE TYPE

open access: yesIus et Praxis, 2009
El trabajo se aproxima al tema de la interpretación de la Constitución a través de la "ley interpretativa", nuevo tipo de ley incorporada a la taxonomía del artículo 66, y que posee, dada su naturaleza o contenido material, un carácter excepcional y ...
Francisco Zúñiga Urbina
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

The sound emission as the basis of interpretative culture formation of piano student [PDF]

open access: yes, 2013
The sound emission in achieving the musical and interpretative act in piano class is conceived by the authors as a current, interesting and complex one.
Гранецкая, Лилия   +1 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Legal nature of the interpretative acts of the Constitutional Court of Ukraine [PDF]

open access: yes, 2012
У статті наведені результати наукового аналізу правової природи інтерпретаційних актів Конституційного Суду України. Автором досліджено особливості інтерпретаційних актів Конституційного Суду України.This article deals with the results of scientific ...
Shevchuk, Iryna M.   +1 more
core  

Note sur la mémoire du lecteur de L’Éducation sentimentale

open access: yesFlaubert: Revue Critique et Génétique, 2019
In L’Education sentimentale, almost all reminders of what has already been narrated occur through the protagonist’s consciousness. The reminders of the final two chapters differ, however, by their dialogical character, as well as by their frequency ...
Guillaume Perrier
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

A BIOSEMIOTIC APPROACH TO THE QUESTION OF MEANING

open access: yesZygon, 2010
A sign is something that refers to something else. Signs, whether of natural or cultural origin, act by provoking a receptive system, human or nonhuman, to form an interpretant (a movement or a brain activity) that somehow relates the system to this ...
doaj   +2 more sources

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