Results 41 to 50 of about 2,246,452 (303)

A statistical analysis plan for the Adjunctive Corticosteroids for Tuberculous meningitis in HIV-positive adults (ACT HIV) clinical trial. [PDF]

open access: yes, 2021
TBM is the most severe form of tuberculosis. Clinical trial data are required to provide an evidence base for adjunctive dexamethasone in HIV-positive individuals with TBM, and to guide clinical practice.
Ronald B. Geskus   +9 more
core   +1 more source

Las nuevas tecnologías, una herramienta al servicio de la presentación del Patrimonio. El caso del Parque Arqueológico Minas de Gavà (Barcelona)

open access: yesVirtual Archaeology Review, 2010
The Gava Mines Archaeological Park (Gavà, Spain) is an interpretative centre created in order to achieve a global project in the Prehistoric Mines site, the oldest mines made in galleries in Europe.
Mònica Borrell Giró
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

The Coconut Day: A poetic Interpretation of Seizure Experiences [PDF]

open access: yes, 2013
: This article presents a fraction of an interpretative phenomenological analysis (IPA) of people's seizure (ictal) experiences. In addition to undertaking individual analyses and across case analyses, a poetic interpretation (SZTO, FURMAN & LANGER ...
Featherstone, Valerie A.
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Lessons learned from ACT for Youth: The first five years [PDF]

open access: yes, 2007
This report describes how ACT for Youth unfolded over the first five years, identifying common themes and lessons learned across the eleven community partnerships that made up the first round of the ACT for Youth initiative.
ACT for Youth Center of Excellence
core  

Si può interpretare la musica elettroacustica?

open access: yesAisthesis, 2014
Stephen Davies distinguishes two kinds of musical works: works for performance and works that are not for performance. He argues that electroacoustic music belongs to the latter kind.
Eric Maestri
doaj   +3 more sources

Moses under investigation: Sigmund Freud and the Borgean labyrinth

open access: yesRevista Criação & Crítica, 2012
This paper aims to provide an interpretative intersection between Sigmund Freud's “Moses and Monotheism” and Jorge Luis Borges' short story “Death and the Compass” (“La muerte y la brújula”).
Patrícia de Oliveira Leme
doaj   +1 more source

The interpretation of the law: act of knowledge or act of will?

open access: yesStudia Universitatis Moldaviae. Seria Stiinte Sociale
The issue of interpretation of the law has enjoyed increased attention from the legal doctrine and practice during the centuries. Both the natural-law school and the normative theory with its positivist version have pleaded to define the interpretation as an activity that focuses on the significance of the norm, the act or human conduct. The divergence
Elena Arama, Valentina Coptilet
openaire   +1 more source

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