Results 91 to 100 of about 2,246,452 (303)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Estudios de Teoría Literaria, 2023 This article examines various censorship marks that TikTok’s users have made on their copies of Harry Potter to erase the name of its author. In contrast to institutional censorship, censorship found in Harry Potter arises from franchise's readers and ...
Isidora D. Raby
doaj
Hegel y Aristóteles: Una lectura de Metafísica XII, 7,1072b 18-30
Tópicos, 2013 The author does a hegelian interpretation of Metaphysics XII, 7, 1072b 18-30, passage with which the Encyclopedia of the Philosophical Sciences concludes. Here are drawn the relations and similitudes that exist between Aristotle's Unmoved Mover and Hegel'
Luis Xavier López-Farjeat
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
The Quest for Deeper Understanding in Interpretative Research: Hidden Meaning in Plain Sight [PDF]
, 2020 This paper contributes to the literature on qualitative methodology in a novel way, by being one of a handful of studies offering context and culture-bound insights of an interpretative analysis of meaning based on non-verbal communication from 49 semi ...
Knowles, D., Chitac, I., Dhaliwal, S.
core
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
The role of section 2(1) and (4) of the European Communities Act and section 3(1) of the Human Rights Act in the interpretation and application of primary legislation: impact on judicial attitudes to the traditional concept of parliamentary sovereignty [PDF]
The main aim of this thesis is to examine, through an analysis of relevant case law, the way in which the courts interpret and apply primary legislation pursuant to the interpretative obligation contained in section 2(1) and (4) of the European ...
Okorodas, Anthony
core
Studia z Zakresu Prawa Pracy i Polityki SpołecznejThe purpose of this article is to draw attention to the still relevant issue of the normative character of the so-called autonomous sources of labour law. The author focuses primarily on the statutory
Jakub Rumian
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source