Results 61 to 70 of about 77,843 (262)

Interrogative structures in the written didactic discourse [PDF]

open access: yesDiversitate si Identitate Culturala in Europa, 2023
This paper starts from the premise that interrogative structures have significant impact on verbal behaviour and human behaviour, in general. Our analysis of this particular type of discourse is based on the assertions of E. Benveniste, according to whom
Constantin-Georgel STOICA
doaj  

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Tactical Techniques in the Production of Interrogation

open access: yesСибирское юридическое обозрение, 2019
Based on traditional and modern studies of forensic scientists and specialists in the field of legal procedures, regulatory sources; the practice of investigating criminal cases in the article covers both the general provisions of the interrogation ...
L. Yu. Aksenova, A. T. Anesheva
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

APA: Denunciation and Accommodation of Abusive Interrogations: A Lesson for World Psychology

open access: yesPsicologia, 2008
In the wake of the air attacks on the United States in September 2001, counterterrorism policy in the George W. Bush Administration involved psychologists in design and implementation of abusive interrogations of foreign detainees.
Jean Maria Arrigo, Jancis Long
doaj  

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

open access: yesFEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta   +7 more
wiley   +1 more source

THE CRIMINAL PROCEDURAL PHENOMENON OF THE OATH: A LEGAL RUDIMENT OR AN UNDERVALUED PUBLIC LAW PROCEDURE?

open access: yesПравовое государство: теория и практика
The author’s scientific focus is on the question of whether the oath, as a procedural mechanism, is an outdated legal rudiment that has irretrievably lost its relevance in the context of modern criminal justice, or whether the oath should be considered a
LATYPOV Vadim Sagit'yanovich
doaj   +1 more source

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