Results 71 to 80 of about 77,843 (262)

A reflexion as method of setting of psychological contact with interrogated on pre-trial investigation

Теорія і практика правознавства, 2016
The problem setting. The article is devoted to the issue of the day of establishment of psychological contact at conducted to the interrogation on pre-trial investigation.
В. В. Баранчук
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

La « curiosité bizarre » de Baudelaire et Musset : explorations, interrogations et subversions

Quêtes Littéraires
Alors que les violentes critiques de Baudelaire envers Musset présupposent une incompatibilité fondamentale entre ces auteurs, de nombreux points communs, dont leur intérêt pour le bizarre, révèlent une continuité entre le mal du siècle mussétien et le ...
Laëtitia Bertrand
doaj   +1 more source

Lysias interrogating Eratosthenes on the murder of Polemarchus (Lys. 12.26)

Erga-Logoi, 2018
Eratosthenes arrested Polemarchus, following the orders of the Thirty to seize the money of the metics, and then he brought him to the Council, where he was condemned to death without a proper trial.
Angelos Kapellos
doaj   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Some criminalistic problems of on-site testimony verification involving minor participants

Ученые записки Казанского университета: Серия Гуманитарные науки
Given the large number of crimes committed by minors, despite the downward trend in their dynamics, the involvement of minor offenders in criminal proceedings as a distinct group of procedural actors has become inevitable.
R. I. Zainullin
doaj   +1 more source

Les… interrogations de Philippe Djian [PDF]

Synergies Algerie, 2017
Depuis 2012, les récits fictifs ou métatextuels de l’écrivain français Philippe Djian témoignent d’une volonté d’abolir l’usage orthodoxe de la ponctuation. L’auteur pense que les signes épilinguistiques ont une force sémantique aussi importante que les
Myriam Bouchoucha
doaj  

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source