Results 151 to 160 of about 726,838 (342)

Impact of the COVID-19 pandemic on the services provided by the Peruvian health system: an analysis of people with chronic diseases

Scientific Reports
During the pandemic, many individuals with chronic or infectious diseases other than COVID-19 were unable to receive the care they needed due to the high demand for respiratory care.
David Villarreal-Zegarra, Luciana Bellido-Boza, Alfonso Erazo, Max Pariona-Cárdenas, Paul Valdivia-Miranda   +4 more
doaj   +1 more source

Combined effect of PCV10 and meningococcal C conjugate vaccination on meningitis mortality among children under five years of age in Brazil

Human Vaccines & Immunotherapeutics, 2018
The 10-valent pneumococcal conjugate vaccine (PCV10) was introduced in the Brazilian National Immunization Program in March 2010, scheduled at 2, 4, and 6 months, with a booster at 12–15 months of age.
Ana Luiza Bierrenbach, Ruth Minamisava, Airlane Pereira Alencar, Gizelton Pereira Alencar, Ana Lucia Andrade   +4 more
doaj   +1 more source

The Effect of the 18-Year Old Drinking Age on Auto Accidents [PDF]

, 1974
The effect of Massachusetts' reduced drinking age on auto accidents is examined by employing an interrupted time series analysis of monthly accident data covering the period January, 1969, through September 1973.
Cucchiaro, Stephen, Ferreira, Joseph Jr., Sicherman, Alan   +2 more
core  

Suicide numbers during the first 9-15 months of the COVID-19 pandemic compared with pre-existing trends: An interrupted time series analysis in 33 countries

EClinicalMedicine, 2022
J. Pirkis, D. Gunnell, Sangsoo Shin, Marcos Del Pozo-Banos, Vikas Arya, Pablo Analuisa Aguilar, L. Appleby, S. Arafat, E. Arensman, J. Ayuso-Mateos, Y. Balhara, J. Bantjes, A. Baran, C. Behera, J. Bertolote, Guilherme Borges, Michael Bray, P. Brečić, E. Caine, R. Calati, V. Carli, G. Castelpietra, L. Chan, Shu-Sen Chang, D. Colchester, Maria Coss-Guzmán, D. Crompton, Marko Ćurković, R. Dandona, Eva de Jaegere, D. de Leo, E. Deisenhammer, J. Dwyer, A. Erlangsen, J. Faust, M. Fornaro, S. Fortune, Andrew Garrett, G. Gentile, R. Gerstner, R. Gilissen, M. Gould, S. Gupta, K. Hawton, F. Holz, I. Kamenshchikov, N. Kapur, A. Kasal, Murad Khan, Olivia J. Kirtley, D. Knipe, K. Kõlves, S. Kölzer, Hryhorii Krivda, S. Leske, F. Madeddu, A. Marshall, A. Memon, E. Mittendorfer-Rutz, Paul Nestadt, N. Neznanov, T. Niederkrotenthaler, E. Nielsen, M. Nordentoft, H. Oberlerchner, R. O’Connor, Rainer Papsdorf, T. Partonen, M. Phillips, Steven I. Platt, G. Portzky, G. Psota, P. Qin, Daniel Radeloff, A. Reif, C. Reif-Leonhard, M. Rezaeian, Nayda Román-Vázquez, S. Roškar, V. Rozanov, Grant Sara, Karen Scavacini, Barbara Schneider, N. Semenova, M. Sinyor, S. Tambuzzi, E. Townsend, Masahito Ueda, D. Wasserman, R. Webb, P. Winkler, P. S. Yip, G. Zalsman, R. Zoja, A. John, M. Spittal   +95 more
semanticscholar   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Impact of an Educational Intervention on BPPV Management: An Interrupted Time Series Analysis

Algorithms
This study evaluates the impact of an educational intervention aimed at improving the management of benign paroxysmal positional vertigo (BPPV) in a clinical setting.
Erfan Arbab, Kalpdrum Passi, Robert Ohle
doaj   +1 more source

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

A Self‐Organized Liquid Reaction Container for Cellular Memory

Advanced Science, EarlyView.
How cells restore epigenetic information lost during replication is not known. This work proposes a mechanism based on the formation of biomolecular condensates. These condensates are induced by the chromosome itself and serve as reaction vessels for reconstructing missing epigenetic markers.
Sukanta Mukherjee, Enrico Skoruppa, Holger Merlitz, Jens‐Uwe Sommer, Helmut Schiessel   +4 more
wiley   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source