Results 41 to 50 of about 35,337,675 (295)

Handling Missing Values in Interrupted Time Series Analysis of Longitudinal Individual-Level Data

Clinical Epidemiology, 2020
Juan Carlos Bazo-Alvarez,1,2 Tim P Morris,3 Tra My Pham,3 James R Carpenter,3,4 Irene Petersen1,5 1Research Department of Primary Care and Population Health, University College London (UCL), London, UK; 2Instituto de Investigación, Universidad Cat&
Bazo-Alvarez JC, Morris TP, Pham TM, Carpenter JR, Petersen I   +4 more
doaj  

Severe cyclones and sex-specific birth outcomes in Queensland, Australia: An interrupted time-series analysis

, 2023
Objectives: A male is less adaptable to biological stressors than a female fetus with consequent higher morbidity and mortality. Adverse birth outcomes increase and male livebirths decrease after environmental disasters, economic crises, and terrorist ...
Harley, D, Richardson, A, Parayiwa, C, Behie, A   +3 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The effect of Share 35 on biliary complications: An interrupted time series analysis [PDF]

American Journal of Transplantation, 2019
The purpose of the Share 35 allocation policy was to improve liver transplant waitlist mortality, targeting high MELD waitlisted patients. However, policy changes may also have unintended consequences that must be balanced with the primary desired outcome. We performed an interrupted time series assessing the impact of Share 35 on biliary complications
J N, Fleming, D J, Taber, D, Axelrod, K D, Chavin   +3 more
openaire   +2 more sources

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

ASSESSMENT OF THE IMPACT OF THE COVID-19 PANDEMIC ON HIV INDICATORS IN BRAZIL: A TIME-SERIES ANALYSIS

Brazilian Journal of Infectious Diseases
Introduction: In March 2020, the World Health Organization declared the onset of the COVID-19 pandemic caused by SARS-CoV-2. This global crisis overwhelmed healthcare systems, including in Brazil, adversely affecting the control of several infectious ...
Beatriz Sousa-Peres, Sarah Maiche, Klauss Villalva-Serra, Artur T.L. Queiroz, Moreno M.S. Rodrigues, Bruno B. Andrade, Mariana Araújo-Pereira   +6 more
doaj   +1 more source

Effect of the COVID‐19 pandemic on the frequency of emergency department visits in Portugal: An interrupted time series analysis until July 2021

Journal of the American College of Emergency Physicians Open, 2023
Objectives This study aims to evaluate the effect of the COVID‐19 pandemic on the frequency of emergency department (ED) visits in Portugal between March 2020 and July 2021.
Sílvia Lopes, Patrícia Soares, Joana Santos Sousa, João Victor Rocha, Paulo Boto, Rui Santana   +5 more
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Continuity of community-based healthcare provision during COVID-19: a multicountry interrupted time series analysis

BMJ Open, 2022
Background Pandemics often precipitate declines in essential health service utilisation, which can ultimately kill more people than the disease outbreak itself.
Caroline Whidden, Daniel Palazuelos, Madeleine Ballard, Jane Yang, Molly Christiansen, Carey Westgate, Amanda Yembrick, Diego Lassala, Fabien Munyaneza, Helen E Olsen, Anoushka Millear, Dianne Thakura, Afra Nuwasiima, Daniele J Ressler, Wycliffe Okoth Omwanda   +14 more
doaj   +1 more source