Results 41 to 50 of about 7,909 (301)

Standing Waves in the FitzHugh-Nagumo System and a Problem in Combinatorial Geometry

open access: yes, 2006
We show that there is a close relation between standing-wave solutions for the FitzHugh-Nagumo system \[ \Delta u +u(u-a)(1-u) - \delta v=0, \ \ \Delta v-\delta \gamma v + u=0 \ \ \mbox{in} \ R^N,\] \[ u, v \to 0 \ \mbox{as} \ |x| \to +\infty ...
Winter, M   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Electromagnetic wave diffraction by a system of non-intersecting obstacles of various dimensions

open access: yes, 2015
The vector problem of time-harmonic electromagnetic wave diffraction by a system of non-intersecting solid inhomogeneous bodies, infinitely thin perfectly conducting screens and wire antennas is considered. The original boundary value problem for Maxwell’
Medvedik, M. Y.,   +7 more
core   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz   +3 more
wiley   +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle   +4 more
wiley   +1 more source

A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley   +1 more source

Self-intersecting marginally outer trapped surfaces

open access: yes, 2019
We have shown previously that a merger of marginally outer trapped surfaces (MOTSs) occurs in a binary black hole merger and that there is a continuous sequence of MOTSs which connects the initial two black holes to the final one.
Birnholtz, O.   +3 more
core   +1 more source

Perturbative superstrata [PDF]

open access: yes, 2013
Issued under a Creative Commons Attribution LicenceS.G. has been partially supported by MIUR-PRIN contract 2009-KHZKRX, by the Padova University Project CPDA119349 and by INFN. R.R.
Rodolfo Russo   +5 more
core   +1 more source

Impact of joint distribution within hard rock mass on tunnel blasting profile: Numerical simulation and field measurement

open access: yesJournal of Rock Mechanics and Geotechnical Engineering
In hard rock tunnel excavation, controlling the blasting profile to prevent overbreak and underbreak is critical for safety and cost-effectiveness. Discontinuities such as joints and faults significantly affect the mechanical properties of the rock mass,
Junxin Li   +4 more
doaj   +1 more source

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