Results 31 to 40 of about 68,355 (266)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Intersecting and Cross-Intersecting Families of Labeled Sets [PDF]
The Electronic Journal of Combinatorics, 2008 A family ${\cal A}$ of sets is said to be intersecting if any two sets in ${\cal A}$ intersect. Families ${\cal A}_1, ..., {\cal A}_p$ are said to be cross-intersecting if, for any $i, j \in \{1, ..., p\}$ such that $i \neq j$, any set in ${\cal A}_i$ intersects any set in ${\cal A}_j$. For ${\bf k} = (k_1, ..., k_n) \in {\Bbb N}^n$, $2 \leq k_1 \leq ..
openaire +4 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
William Least Heat-Moon’s American Travels: Representing Spaces through the American Road Narrative [PDF]
IntersectionsWilliam Least Heat-Moon embarked on a road trip across the United States in 1978, after having lost his job as a professor and after divorcing. With his van, called Ghost Dancing, after Native American ceremonies, Heat-Moon hits the open road for three ...
Alice Carletto
doaj +1 more source
The intersection of retracts of A∗
Theoretical Computer Science, 2000 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +1 more source