Results 41 to 50 of about 68,355 (266)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

“Flowing Perpetually Outward”: Quest and Journey in Terrence Malick’s The Thin Red Line (1998) [PDF]

Intersections
North American director Terrence Malick’s films poetically explore inner journeys that, particularly in his early work, deeply engage with the narratives surrounding the American Dream, often intertwining these with literal journeys.
Filipa Rosário
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Quand tout se mêle et s’emmêle : Rouletabille en Russie ou le reporter face au complot

Sociopoétiques
In 1913, Gaston Leroux, a former journalist, published Rouletabille chez le tsar as a serial, the third of eight wise books. By highlighting the stereotypes and intersections characterizing the representations of conspiracy that inform it, the novel also
Jean-Baptiste LEGAVRE
doaj   +1 more source

Aesthetic Heathenism: Pagan Revival in Extreme Metal Music

Intersections, 2020
Neopaganism, briefly defined as the attempt to reconstruct and reinterpret pre-Christian heritage, is not confined to purely religious movements. A romanticized view of ancestral religion particularly expressed through an extensive use of mythological ...
Irina-Maria Manea
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Assessing urban traffic congestion for sustainable transportation in Chennai, India: a case study of Kathipara and T. Nagar intersections

Frontiers in Sustainable Cities
Urban congestion significantly impairs economic output, energy efficiency, and mobility in India’s fast-expanding cities. This study focuses on Panagal Park, T.
Sridhar Parkavi, Angamuthu Parthiban
doaj   +1 more source

“We Must Get Rid of Slavery, or We Must Get Rid of Freedom.” Self, Other, and Emancipation in Antebellum America [PDF]

Intersections, 2018
Antebellum American literature, like the country itself, was a heterogeny of Romanticism, Transcendentalism, and political prose culminating in the national narrative. Authors during this time struggled with the issue of slavery and their works reflected
Carrie Forsberg
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Exploring Driver Trajectory Preferences for Unprotected Left Turns and the Impact on Traffic Safety

Promet (Zagreb)
The behaviour of drivers making left turns is complex, significantly affecting the safety of intersection operations. Some drivers disregard the right-of-way rules when making left turns, leading to contention with vehicles going straight, causing ...
Xiaobo HAN, Pengfei LIU, Yinglong HE, Muhammad Awais SHAFIQUE, Jing ZHAO   +4 more
doaj   +1 more source