Results 151 to 160 of about 10,296 (263)

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu   +6 more
wiley   +1 more source

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza   +2 more
wiley   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz   +3 more
wiley   +1 more source

Joint Angular Excursions and Angular Range Utilization During Stance‐Phase Locomotion in Terrestrial Mammals: A Comparative Morphofunctional Data Set

open access: yesJournal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
This study quantifies stance‐phase joint angular excursions and angular utilization (AUI%) during walking in 182 terrestrial mammal species. Across mammals, total limb excursion during stance (TAE) decreases with increasing body mass, whereas AUI% remains broadly conserved, indicating similar proportional use of summed joint excursions to generate net ...
Paul Medina‐González
wiley   +1 more source

fCUT&Tag‐Seq: An optimized CUT&Tag‐based method for high‐resolution profiling of histone modifications and chromatin‐binding proteins in fungi

open access: yesmLife, EarlyView.
Abstract Histone modifications and chromatin‐binding proteins play crucial roles in regulating gene expression in eukaryotes, with significant implications for fungal pathogenicity and development. However, profiling these modifications or proteins across the genome in fungi remains challenging due to the technical limitations of the traditional ...
Haiting Wang   +11 more
wiley   +1 more source

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