Results 111 to 120 of about 24,520 (298)

Integrated biomarker landscape for the early detection and management of calcific aortic valve disease

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Calcific aortic valve disease (CAVD), the leading valvular disorder in older adults, progresses from sclerosis to severe stenosis without effective medical therapies, making early non‐invasive detection essential. Circulating and mechanistic biomarkers reflect core pathogenic axes, including lipid oxidation, inflammation, mineral metabolism ...
Alberto Cook‐Calvete, Silvia Moreta, Maria Delgado‐Marin, Blanca Fernandez‐Rodriguez, Carlos Zaragoza, Marta Saura   +5 more
wiley   +1 more source

Pulse-Administered Toceranib Phosphate Plus Lomustine for Treatment of Unresectable Mast Cell Tumors in Dogs. [PDF]

, 2015
BackgroundNonresectable mast cell tumors (MCT) in dogs remain a therapeutic challenge, and investigation of novel combination therapies is warranted. Intermittent administration of tyrosine kinase inhibitors (TKI) combined with cytotoxic chemotherapy may
Avery, AC, Axiak-Bechtel, SM, Burton, JH, Clifford, CA, Thamm, DH, Vail, DM, Venable, RO, Williams, LE   +7 more
core   +1 more source

ANO1 in intramuscular interstitial cells of Cajal plays a key role in the generation of slow waves and tone in the internal anal sphincter

Journal of Physiology, 2017
The internal anal sphincter develops tone important for maintaining high anal pressure and continence. Controversy exists regarding the mechanisms underlying tone development.
Caroline A Cobine, E. Hannah, M. H. Zhu, H. E. Lyle, J. Rock, K. Sanders, S. Ward, K. Keef   +7 more
semanticscholar   +1 more source

Spontaneous enteric nervous system activity generates contractile patterns prior to maturation of gastrointestinal motility

Neurogastroenterology &Motility, Volume 38, Issue 1, January 2026.
Spontaneous neuronal network activity is critical for circuit maturation, yet whether this is a feature of enteric nervous system development has yet to be established. Here, we identify clustered ripples, a previously undescribed form of neurogenic gastrointestinal motility that shares many features with spontaneous neuronal networks in other systems.
Lori B. Dershowitz, Hassler Bueno Garcia, Andrew S. Perley, Todd P. Coleman, Julia A. Kaltschmidt   +4 more
wiley   +1 more source

Diabetic gastroenteropathy: Associations between gastrointestinal symptoms, motility, and extraintestinal autonomic measures

Neurogastroenterology &Motility, Volume 38, Issue 1, January 2026.
We found no associations between gastrointestinal and extraintestinal measures of diabetic autonomic neuropathy. Nonetheless, gastrointestinal symptoms increased with the severity of cardiovascular autonomic neuropathy and were associated with gastrointestinal measures.
Ditte S. Kornum, Christina Brock, Tina Okdahl, Davide Bertoli, Huda Kufaishi, Anne‐Marie Wegeberg, Katrine L. Høyer, Esben B. Mark, Birgitte Brock, Christian S. Hansen, Filip K. Knop, Asbjørn M. Drewes, Klaus Krogh   +12 more
wiley   +1 more source

The Expression and Regulation of Chemokines (CXCL9, CXCL10, CXCL11) in Urinary Bladder Inflammation of the Mouse [PDF]

, 2017
Interstitial cystitis is a serious chronic condition that causes bladder pain and increased voiding frequency in millions of adults in the US, most of them women.
Guo, Michael
core   +1 more source

Smooth Muscle Mechanosensitivity Generates and Maintains Pressure Gradients Across the Intestine

Neurogastroenterology &Motility, Volume 38, Issue 1, January 2026.
Mechanosensitivity of the smooth muscle induces a positive‐feedback loop that spontaneously generates pressure gradients across gut segments and stabilizes initially applied pressure gradients. It can act jointly or compete with the pressure gradient induced by directional peristaltic waves.
Richard J. Amedzrovi Agbesi, Lucas Chassatte, Nicolas R. Chevalier   +2 more
wiley   +1 more source

CT features, mimics and atypical presentations of gastrointestinal stromal tumor (GIST)

Indian Journal of Radiology and Imaging, 2011
The term stromal tumor was coined in 1983 by Clark and Mazur for smooth muscle neoplasm of the gastrointestinal tract (GIT). Gastrointestinal stromal tumors (GIST) are nonepithelial tumors arising from the interstitial cells of Cajal, which express KIT ...
Smiti Sripathi, KV Rajagopal, Rajendra Kumar Srivastava, Anurag Ayachit   +3 more
doaj   +1 more source

Gastrointestinal Stromal Tumor (GIST) in Long Standing Crohn’s disease on Anti-TNF Therapy [PDF]

, 2020
Introduction Patients suffering from inflammatory bowel disease (IBD) are at increased risk for developing cancer. Adenocarcinomas are the most commonly observed tumors of the gastrointestinal tract whereas data on gastrointestinal stromal tumor (GIST ...
Davis, Brian, Lippman, H R, Mendel, David, Syed, Taseen   +3 more
core   +1 more source

SOCE mediated by STIM and Orai is essential for pacemaker activity in the interstitial cells of Cajal in the gastrointestinal tract

Science Signaling, 2018
Refilling ER Ca2+ stores through SOCE enables the interstitial cells of Cajal to trigger pacemaker activity in the gut. Keeping the gut moving The gut contracts periodically to mix and propel its contents.
Haifeng Zheng, Bernard T. Drumm, S. Earley, T. Sung, S. D. Koh, K. Sanders   +5 more
semanticscholar   +1 more source