Results 51 to 60 of about 10,940 (177)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

From Dismissal to Partnership: Patient Experiences of Recurrent Urinary Tract Infection Healthcare Informed by the Theoretical Domains Framework and Behaviour Change Theory

Health Expectations, Volume 29, Issue 2, April 2026.
ABSTRACT Background Recurrent urinary tract infection (rUTI) is common, debilitating, and associated with substantial negative impact on quality of life. Despite this, rUTI healthcare is often experienced as fragmented, dismissive, and poorly aligned with patient needs.
Abigail F. Newlands, Melissa L. Kramer, Sarah Snuggs, Katherine A. Finlay   +3 more
wiley   +1 more source

Causal effects of gut microbiota on risk of interstitial cystitis: a two-sample Mendelian randomization study

Frontiers in Microbiology
BackgroundThe correlation between gut microbiota and interstitial cystitis has garnered significant attention in previous studies. Nevertheless, the causal relationship between them remains to be clarified.MethodsGenetic variation serves as a tool in ...
Jianguo Gao, Sihai Shao, Yuefan Shen
doaj   +1 more source

Pre‐Existing Nocturia Status Predicts Bladder Symptom Exacerbation Following COVID‐19 Vaccination in Women

The Kaohsiung Journal of Medical Sciences, EarlyView.
Hsien‐Che Ou, Hao‐Wei Chen, Yung‐Shun Juan, Yu‐Chen Chen   +3 more
wiley   +1 more source

The Association Between Partner Reactions to Chronic Pain and Pain‐Related Outcomes: A Systematic Review

European Journal of Pain, Volume 30, Issue 3, March 2026.
ABSTRACT Background and Objective It has long been recognised that the social context, including partner relationships, can impact the chronic pain experience and pain outcomes. The goal of this systematic review is to analyse, appraise and integrate the current evidence regarding the relationships between partner reactions to chronic pain behaviours ...
G. F. Donohue, P. J. Meredith, J. Strong, L. Page, N. E. Andrews   +4 more
wiley   +1 more source

Microbiome‐urothelium crosstalk in bladder cancer: From dysbiosis to clinical translation

iMetaOmics, Volume 3, Issue 1, March 2026.
This review elucidates the critical crosstalk between the urobiome and bladder cancer (BCa), mapping the landscape from ecological dysbiosis to clinical translation. We synthesize emerging evidence on microbial signatures that distinguish BCa patients, exploring key carcinogenic mechanisms including chronic inflammation, genotoxicity, and the gut ...
Haoxiang Xu, Zhibiao Li, Lin Yang, Jun Zheng, Weijia Li, Rulin Liao, Wenxue Huang, Boyuan Sun, Zhuohang Li, Cunzhen Ma, Xunguo Yang, Zongwei Wang, Jie Zhao, Bisheng Cheng, Peng Wu   +14 more
wiley   +1 more source

Comparing Movement Patterns and Physical Function Between Chronic Low Back Pain Patients With Nociplastic and Nociceptive Pain Categories

JOR SPINE, Volume 9, Issue 1, March 2026.
Are differences in perceived disability between nociceptive and nociplastic cLBP patients reflected in actual movement patterns or in patients' perceived functional ability? Despite worse patient‐reported disability, primarily nociplastic patients did not exhibit worse biomechanical function when compared to primarily nociceptive patients.
Erin Archibeck, Nicholas Harris, Patricia Zheng, Aaron Scheffler, Wolf Mehling, Conor O'Neill, Jeffrey Lotz, Grace O'Connell, Jeannie F. Bailey, REACH Investigators, Zehra Akkaya, Prakruthi Amarkumar, Jeannie Bailey, Julia Barylak, Sigurd Berven, Andrew Bishara, Dennis M. Black, Noah Bonnheim, Atul Butte, Joel Castellanos, Jennifer Cummings, Karina Del Rosario, Emilia Demarchis, Sibel Demir‐Deviren, Susan K. Ewing, Adam R. Ferguson, Aaron Fields, Scott M. Fishman, Sergio Garcia Guerra, Fatemeh Gholi Zadeh Kharrat, Xiaojie (Summer) Guo, Misung Han, Trisha Hue, J. Russell Huie, C. Anthony Hunt, Anastasia Keller, Karim Khattab, Roland Krug, Gregorji Kurillo, Feng Lin, Thomas Link, Jeffrey Lotz, John Lynch, Tong Lyu, Rob Matthew, Wolf Mehling, Esmeralda Mendoza, Praveen Mummaneni, Caroline Navy, Conor O’Neill, Jessica Ornowski, Thomas Peterson, Ananya Rupanagunta, Aaron Scheffler, Shalini Shah, Irina Strigo, Naoki Takegami, Abel Torres‐Espin, Salvatore Torrisi, Sachin Umrao, Rohit Vashisht, Joanna Veres, An (Joseph) Vu, Mark Steven Wallace, Lucy Ann Wu, Po‐Hung Wu, Fadel Zeidan, Patricia Zheng, Jiamin Zhou   +68 more
wiley   +1 more source

Co-morbidities of Interstitial Cystitis

Frontiers in Neuroscience, 2012
Introduction: This study aimed to estimate the proportion of patients with Interstitial Cystitis/Painful Bladder Syndrome (IC/BPS) with systemic dysfunction associated co-morbidities such as irritable bowel syndrome (IBS) and fibromyalgia (FM). Material
Gisela eChelimsky, Elizabeth eHeller, C. Anthony eBuffington, Raymond eRackley, Di eZhang, Thomas eChelimsky   +5 more
doaj   +1 more source

Advances and Prospects of Stereotactic Radiosurgery and Stereotactic Ablative Body Radiotherapy: Evolving Paradigms in Precision Oncology

Med Research, Volume 2, Issue 1, Page 157-180, March 2026.
The graphical abstract outlines the progressive development and impact of stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). Technological Evolution illustrates the transition from brachytherapy with single‐dose, LDR/HDR schedules to fractionated radiotherapy, three‐dimensional conformal radiotherapy (3DCRT) and Gamma Knife ...
Jing Zhang, Wenhao Xu, Weiqing Lu, Yingxuan Lin, Luoxi He, Zonglin Lv, Yiliyaer Nuerrula, Zouting, Zhen Zhang, Hailiang Zhang, Xuejun Ma   +10 more
wiley   +1 more source

Intravesical hyaluronic acid treatment for ketamine-associated cystitis: Preliminary results

Urological Science, 2015
Introduction: Long-term ketamine abuse may cause variable lower urinary tract symptoms (LUTS) and severe cystitis. The clinical features of ketamine-associated cystitis (KC) are very similar to bladder pain syndrome/interstitial cystitis (BPS/IC ...
En Meng, Chih-Wei Tsao, Shou-Hung Tang, Sheng-Tang Wu, Tai-Lung Cha, Guang-Huan Sun, Dah-Shyong Yu, Sun-Yran Chang   +7 more
doaj   +1 more source