Results 91 to 100 of about 3,566,549 (338)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Multi-Objective Interval Prediction of Load Based on the Conditional Copula Function
Applied Sciences, 2019 Compared with the point prediction, the interval prediction of the load could more effectively guarantee the safe operation of the power system. In view of the problem that the correlation between adjacent load data is not fully utilized so that the ...
Gang Zhang +5 more
doaj +1 more source
POS1247 RIGHT VENTRICULAR MORPHOLOGY AND FUNCTION AFTER HIGH INTENSITY INTERVAL AND RESISTANCE TRAINING IN PEOPLE WITH SYSTEMIC SCLEROSIS: A RANDOMISED CONTROLLED PILOT STUDY [PDF]
, 2023 Athanasios C. Mitrοpoulos +11 more
openalex +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Multi-objective interval prediction of wind power based on conditional copula function
Journal of Modern Power Systems and Clean Energy, 2019 Interval prediction of wind power, which features the upper and lower limits of wind power at a given confidence level, plays a significant role in accurate prediction and stability of the power grid integrated with wind power.
Gang Zhang +5 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
On the Extension of Interval Functions [PDF]
Transactions of the American Mathematical Society, 1947 Introduction. The problem of extending the range of definition of a function defined on a class of elementary figures-intervals, rectangles-has been treated in various ways in the literature. In the theory of Lebesgue measure a particular function-length of interval (area of rectangle)-is extended in a completely additive way to an additive class of ...
openaire +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source