Results 91 to 100 of about 1,704,656 (340)
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
Generalized-Hukuhara-Gradient Efficient-Direction Method to Solve Optimization Problems with Interval-valued Functions and its Application in Least Squares Problems [PDF]
arXiv, 2020 This article proposes a general gH-gradient efficient-direction method and a W-gH-gradient efficient method for the optimization problems with interval-valued functions. The convergence analysis and the step-wise algorithms of both the methods are presented.
arxiv
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Using Gradual Numbers to Analyze Non-Monotonic Functions of Fuzzy Intervals [PDF]
arXiv, 2007 Gradual numbers have been introduced recently as a means of extending standard interval computation methods to fuzzy intervals. The literature treats monotonic functions of fuzzy intervals. In this paper, we combine the concepts of gradual numbers and optimization, which allows for the evaluation of any differentiable function on fuzzy intervals, with ...
arxiv
Molecular Oncology, EarlyView.Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric +11 more
wiley +1 more source
Inverse limits with countably Markov interval functions [PDF]
arXiv, 2015 We introduce countably Markov interval functions and show that two inverse limits with countably Markov interval bonding functions are homeomorphic if the functions follow the same pattern. This result presents a generalization of well-known results of S. Holte, and I. Bani\v{c} and T. Lunder.
arxiv
Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane +16 more
wiley +1 more source
Conjugacy and Iteration of Standard Interval Rank in Finite Ordered Sets [PDF]
arXiv, 2014 In order theory, a rank function measures the vertical "level" of a poset element. It is an integer-valued function on a poset which increments with the covering relation, and is only available on a graded poset. Defining a vertical measure to an arbitrary finite poset can be accomplished by extending a rank function to be interval-valued.
arxiv
On the divisor function in short intervals [PDF]
Archiv der Mathematik, 2011 Let d(n) denote the number of positive divisors of the natural number n. The aim of this paper is to investigate the validity of the asymptotic formula $$\begin{array}{lll}\sum \limits_{x < n \leq x+h(x)}d(n)\sim h(x)\log x\end{array}$$ for
openaire +3 more sources
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source