Results 121 to 130 of about 9,738 (308)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A successful rendezvous endoscopic ultrasonography-guided gallbladder drainage in malignant cystic duct obstruction

, 2017
Endoscopic ultrasonography-guided gallbladder drainage (EUS-GBD) has been developed as an alternative drainage method in patients with malignant cystic duct obstruction.
Jongchan Lee, Jong-Chan Lee, Jin-Hyeok Hwang, Jaihwan Kim, Hyoung Woo Kim   +4 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Role of endoscopic ultrasound in non-small cell lung cancer

, 2016
Lung carcinoma is a common cause of mortality and morbidity worldwide. Non-small cell lung cancer (NSCLC) accounts for majority of cases worldwide. Accurate staging of NSCLC is of paramount importance due to marked difference in survival and management ...
Sumit Bhatia, Rajesh Puri
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

EUS-guided pancreatic duct drainage—technical tips and outcomes: narrative review

Therapeutic Advances in Gastroenterology
Endoscopic ultrasound-guided pancreatic duct drainage (EUS-PDD) is becoming an alternative treatment in patients with difficult retrograde access to the pancreatic duct due to difficulty in cannulation or surgically altered anatomy.
Yasunobu Yamashita, Masayuki Kitano
doaj   +1 more source

Endoscopic ultrasound—guided duodenojejunostomy for a duodenal duplication cyst presenting with duodenal obstruction

VideoGIE
Background and Aims: Duodenal duplications are rare congenital anomalies that can cause gastrointestinal obstruction. Although surgical resection is the standard treatment, endoscopic alternatives are increasingly being explored.
Shuang Nie, MD, PhD, Lei Wang, MD, PhD, Shanshan Shen, MD, PhD   +2 more
doaj   +1 more source

Technical and clinical efficacy of double endoscopic EUS gastroenteroanastomosis for benign and malignant gastric outlet obstruction

Background: Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is an emerging technique widely described and accepted for the treatment of gastric outlet obstruction (GOO).
ADAMOVIC, M., OUMRARI, S.
core  

Unveiling mediastinal pathology: role of EUS guided fine needle aspiration in diagnosing mediastinal lesions

, 2018
Background: Mediastinal lesion is the focus of investigation in diagnosis of infective, granulomatous or neoplastic pathology of respiratory system. Metastatic mediastinal node assessment is an integral part of oncological management. EUS provides access
Venkatakrishnan, L., S., Mukundan, R., Vishnu Abishek   +2 more
core   +1 more source