Results 131 to 140 of about 9,738 (308)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Approach to management of bleeding during EUS-guided liver biopsy: salvage therapy using absorbable gelatin sponge

VideoGIE
Background and Aims: EUS-guided liver biopsy (EUS-LB) has emerged as a reliable alternative to interventional radiology–guided biopsy, offering comparable specimen adequacy. Bleeding remains the most common adverse event.
Frances Dang, MD, MSc, David Cheung, MD, Michael Andrew Yu, MD, Usman Rahim, MD, Joshua Kwon, MD, Amirali Tavangar, MD, Jason Samarasena, MD, MBA, Kenneth Chang, MD   +7 more
doaj   +1 more source

La COVID-19 et ses impacts sur la violence conjugale et la violence envers les enfants : ce que nous disent la recherche et la pratique

, 2021
Bien que nécessaires, les mesures de confinement et de distanciation sociale mises en place pour freiner la propagation du coronavirus sont susceptibles d’être associées à une hausse du risque de violence conjugale (VC) et de violence envers les enfants (
Dubé, Myriam, Vargas Diaz, Rosita, Lessard, Geneviève, Lavergne, Chantal   +3 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Dynamic URP: Revisiting Urethral Retro-Resistance Pressure for Contemporary Sphincter-Targeted Therapy

Diagnostics
This paper introduces a new conceptual framework for interpreting urethral retro-resistance pressure (URP) as a dynamic, intra-procedural tool—ΔURP—for evaluating external urethral sphincter (EUS) engagement during injection therapy.
Nicole Fleischmann
doaj   +1 more source

Clinical outcomes of EUS-guided drainage of debris-containing pancreatic pseudocysts: a large multicenter study

, 2017
Background and study aims Data on clinical outcomes of endoscopic drainage of debris-free pseudocysts (PDF) versus pseudocysts containing solid debris (PSD) are very limited. The aims of this study were to compare treatment outcomes between patients with
Mouen Khashab, Petros Benias, David Carr-Locke, Jonathan Buscaglia, Steven Edmundowicz, Tyler Stevens, Anoop Prabhu, DeWitt, John M., Gonzalez, Susana, Juan Bucobo, Patrick Yachimski, Buscaglia, Jonathan M., Vargo, John J., John DeWitt, Benias, Petros, Andrew Wang, Diehl, David L., Carr-Locke, David L., Draganov, Peter V., John Vargo, Yang, Dennis, Keswani, Rajesh N., Dennis Yang, Mihir Wagh, Bucobo, Juan Carlos, Daniel Mullady, Susana Gonzalez, DiMaio, Christopher J., Khara, Harshit S., Wang, Andrew Y., Sunil Amin, Goodman, Adam J., Srinadh Komanduri, Wagh, Mihir S., Amin, Sunil, Watson, Rabindra R., Richard Kwon, Prabhu, Anoop, Harshit Khara, David Diehl, Rabindra Watson, Peter Draganov, Edmundowicz, Steven A., Nagula, Satish, Adam Goodman, Satish Nagula, Mullady, Daniel, Komanduri, Srinadh, Christopher DiMaio, Khashab, Mouen A., Kwon, Richard S., Yachimski, Patrick S., Stevens, Tyler, Rajesh Keswani   +53 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Early versus late endoscopic treatment of pancreatic necrotic collections: A systematic review and meta-analysis

Endoscopy International Open, 2023
Faisal Kamal, Muhammad Ali Khan, Wade M. Lee-Smith, Sachit Sharma, Ashu Acharya, Alec E Faggen, Umer Farooq, Zahid I Tarar, Muhammad Aziz, Todd Baron   +9 more
doaj   +1 more source