Results 151 to 160 of about 9,738 (308)

Endoscopic Ultrasonography-Guided Gastroenterostomy Is More Cost Effective Than Surgical Gastrojejunostomy: A Health-Economic Evaluation Alongside a Randomized Trial. [PDF]

United European Gastroenterol J
van de Pavert YL, Opmeer K, Besselink MG, Bijlsma R, Booij DC, Boonstra JJ, Boot J, Bruno MJ, Busch OR, Daams F, Derksen WJM, Fockens P, Kastelijn JB, Koerkamp BG, Hagendoorn J, van Hooft JE, Inderson A, Lammers WJ, Lips DJ, Mieog JSD, Molenaar IQ, Veenhof AAFA, Venneman NG, Verdonk RC, Voermans RP, van Wanrooij RLJ, Welsing PMJ, de Wijkerslooth TR, van Santvoort HC, Moons LMG, van der Meulen MP, Vleggaar FP, Dutch Pancreatic Cancer Group.   +32 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Endoscopic-Ultrasound-Guided Gallbladder Drainage in Patients with Percutaneous Cholecystostomy Drain. [PDF]

J Clin Med
Patel R, Ebrahim M, Goduguchinta V, Khalyfa A, Rehman KU, Randhawa N, Inamullah M, Desai R, Ayub K.   +8 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Pioneering the Use of a Novel Endoscopic Ultrasound Platform for Rectal Endoscopic Ultrasound: A Case Series in Outpatient Management of Rectal Subepithelial Lesions. [PDF]

ACG Case Rep J
Monis C, Hou J, Totah F, Prevallet A, Lim B, Steinberg S, Paez M.   +6 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Phase I/II Prospective Study on Endoscopic Ultrasound-Guided Hepaticogastrostomy as Primary Drainage for Unresectable Malignant Hilar Biliary Obstruction. [PDF]

DEN Open
Ogata T, Hara K, Okuno N, Haba S, Kuwahara T, Matsumoto S, Koda H, Oshiro K.   +7 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

An Atypical Case of Metastatic Esophageal Adenocarcinoma Causing Biliary Obstruction and Duodenal Infiltration Requiring EUS-Guided Choledochoduodenostomy. [PDF]

Clin Med Insights Case Rep
Attieh P, Hazzouri AA, Karam K, Chabni A.   +3 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source