Results 191 to 200 of about 90,995 (334)

Automated Computational Pathology to Assess Degenerative Disc Histology

open access: yesJOR SPINE, Volume 8, Issue 4, December 2025.
We utilized human‐in‐the‐loop active learning methods (1) to develop the first computational pathology model to segment disc tissue (2). These segmentation outputs were used to derive shape and other measures to phenotype disc pathology which were correlated with histological scoring but also provides increased sensitivity to detect differences (3 ...
Richard D. Bell   +4 more
wiley   +1 more source

Vertebral Growth Modulation Through Periosteal Resection and Fixed Length Deformity Overcorrection: Computational and In Vivo Pilot Study

open access: yesJOR SPINE, Volume 8, Issue 4, December 2025.
The feasibility of using growth promoting strategies (vertebral periosteal resection and distraction) was investigated via computational and in vivo analysis. Computational analysis demonstrated that there is an increasing mechanical benefit to utilizing concave distraction over convex compression during spinal deformity correction.
Matthew A. Halanski   +10 more
wiley   +1 more source

Protruded Lumbar Intervertebral Discs in Children

open access: bronze, 1977
T. Egawa   +4 more
openalex   +2 more sources

Age and Spinal Level as Predictors of Lumbar Disc Degeneration in Humans and Mice: A Comparative Analysis

open access: yesJOR SPINE, Volume 8, Issue 4, December 2025.
Mouse models are commonly used to study IVD degeneration and related neurological conditions that especially impact elder population. However, how well mice replicate human pathology remains unclear. This study compared lumbar IVD degeneration patterns across age and spinal levels in humans and mice.
Ravij Mehta   +19 more
wiley   +1 more source

Reduced Shear Modulus and Altered Lamellar Morphology of the Outer Annulus Fibrosus in Painful Intervertebral Disc Degeneration Compared With Tissue From Non‐Surgical Controls

open access: yesJOR SPINE, Volume 8, Issue 4, December 2025.
Disc degeneration (DD) results in a mechanically dysfunctional disc through progressive loss of the intervertebral disc's (IVD) highly organized structure. This study measured shear and structure properties of the outer annulus fibrosus in surgical DD and minimally degenerative (non‐DD) donor individuals.
Taylor J. Bader   +11 more
wiley   +1 more source

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