Results 191 to 200 of about 43,248 (263)

Evaluation of Colombian silk fibroin hydrogels functionalized with recombinant LSECtin for intervertebral disc tissue engineering. [PDF]

PLoS One
Caballero-Méndez LC, Zuluaga-Vélez A, Melchor-Moncada JJ, Quintero-Martinez A, Mongeau L, Nejati S, Sepúlveda-Arias JC.   +6 more
europepmc   +1 more source

A Decade of Leadership and Impact: Celebrating 10 Years of the ORS Spine Section

JOR SPINE, Volume 9, Issue 2, June 2026.
Neharika Bhadouria, Rahul Gawri, Gabriela Graziani, Dennis E. Anderson, Ana V. Chee, Chitra L. Dahia, Ashish Diwan, Morgan B. Giers, Svenja Illien‐Junger, Anthony Kirilusha, David J. Nuckley, Derek H. Rosenzweig, Cheryle Séguin, Dmitriy Sheyn, Graciosa Q. Teixeira, Mauro Alini, Keita Ito, Robert L. Mauck, Daisuke Sakai, Jeannie Bailey, Aaron J. Fields, Sibylle Grad, Sarah E. Gullbrand, Nilsson Holguin, Rita Kandel, Zhen Li, Joshua Li, John T. Martin, Fackson Mwale, Grace D. O'Connell, Devina Purmessur, Nam Vo, Uruj Zehra, Nadeen O. Chahine, Lisbet Haglund, Judith A. Hoyland, Christine L. Le Maitre, Jeffrey C. Lotz, Makarand V. Risbud, Lachlan J. Smith, Simon Tang, James C. Iatridis, Karin Wuertz‐Kozak, Dino Samartzis   +43 more
wiley   +1 more source

Comparative Analysis of Dual‐miRNA Mediated Stimulation of Nucleus Pulposus and Bone Marrow Derived Stem Cells for Intervertebral Disc Repair

JOR SPINE, Volume 9, Issue 2, June 2026.
Nucleus pulposus (NP) and bone marrow derived stem cells (BMSCs) transfected with miRNA‐149‐5p‐mimic and 221‐3p‐inhibitor were evaluated in goat monolayer, microtissue, and ex vivo organ cultures of mild degeneration. miRNA‐treated NP cells demonstrated an anti‐catabolic and pro‐discogenic response in organs, highlighting its potential as a ...
Tara Ní Néill, Niamh Wilson, Jake McDonnell, Fergal J. O'Brien, Caroline M. Curtin, James E. Dixon, Pieter A. J. Brama, Conor T. Buckley   +7 more
wiley   +1 more source

Stress-driven design of intervertebral disc implants and optimization of mechanical and biological performance. [PDF]

J Orthop Translat
Zhang M, Pang S, Wang Y, Xue Y, Wu X, Chen W, Qin YX.   +6 more
europepmc   +1 more source

Pre‐Conditioned Bone Marrow Mesenchymal Stromal Cell‐Derived Secretome Exerts an Anti‐Inflammatory Effect on Degenerative Nucleus Pulposus Cells In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
IL‐1β‐preconditioned BM‐MSC‐derived secretome counteracts inflammation‐driven degeneration in hNPCs. BM‐MSCs were preconditioned with IL‐1β (10 ng/mL) for 24 h, and the resulting secretome (BM‐MSCsec) was collected. Degenerative hNPCs cultured in a 3D alginate bead model were exposed to IL‐1β to reproduce an inflammatory degenerative microenvironment ...
Veronica Tilotta, Gianluca Vadalà, Luca Ambrosio, Giuseppina Di Giacomo, Claudia Cicione, Fabrizio Russo, Rocco Papalia, Vincenzo Denaro   +7 more
wiley   +1 more source

Optimization and comparison of different methods for assessing cell viability in intervertebral disc organ cultures. [PDF]

Front Bioeng Biotechnol
Muerner M, Ma J, Kubincova B, Sprecher CM, Stoddart MJ, Grad S.   +5 more
europepmc   +1 more source

Defining the Human Nucleus Pulposus Microenvironment and Its Impact on Cell Matrix Synthesis and Metabolic Activity

JOR SPINE, Volume 9, Issue 2, June 2026.
Human intervertebral disc nutrient microenvironment. Changes observed in microenvironmental profile as a result of degeneration outlined on upper vertebral body with ranges of each species as reported in previous studies. Oxygen, glucose, and lactate gradients are profiled across the lower disc in both healthy and degenerated states.
Niamh Wilson, Tara Ní Néill, Jake McDonnell, Emily McDonnell, Stacey Darwish, Joseph S. Butler, Conor T. Buckley   +6 more
wiley   +1 more source

The Impact of Exercise on Intervertebral Disc Health: A Systematic Review and Meta-Analysis. [PDF]

Sports Med
Samanna CL, Owen PJ, Mitchell UH, Ehrenbrusthoff K, Saueressig T, Moreira E, Arora NK, Mundell NL, Tait JL, Donath L, Karner V, Belavý DL.   +11 more
europepmc   +1 more source

Evolutionary Specializations of the Human Vertebral Body and Intervertebral Disc in Relation to Bipedalism. [PDF]

Life (Basel)
Hershkovitz I, Latimer B, Abbas J, Hejja M, Medlej B, Rapoport H, Kedar E, Ezra D, Rybak I, Sella Tunis T, Zohar I, Dar G.   +11 more
europepmc   +1 more source

Lactate Metabolism in the Intervertebral Disc: Mechanistic Insights and Pathological Implications. [PDF]

Biomolecules
Zhang T, Feng P, Alexander PG, Lee JY, Sowa GA, Vo NV.   +5 more
europepmc   +1 more source