Results 251 to 260 of about 52,505 (294)

Can Multi‐Vertebral CT‐Based Finite Element Models Accurately Predict Strains? An In Vitro Validation Study

International Journal for Numerical Methods in Biomedical Engineering, Volume 41, Issue 8, August 2025.
The study presents the development of a subject‐specific CT‐based multi‐level FE model of the spine and the comparison of its predictions with in vitro experimental data. CT images, which require assumptions about the intervertebral disc to be made, might not be sufficient to allow the development of an accurate FE model.
Alessandra Aldieri, Chiara Garavelli, Luca Patruno, Marco Palanca, Marco Viceconti   +4 more
wiley   +1 more source

Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress. [PDF]

Front Pharmacol
Zhu Z, Huang Z, Zhang C, Xu B, Chen H, Pei S, Zhang B, Jie L, Shi X, Liu Y, Li Y, Shen X.   +11 more
europepmc   +1 more source

Pharmacokinetics, Safety, and Tolerability of Single‐Dose Dazukibart in Healthy Adults in China and Japan: Results From 2 Randomized, Double‐Blind, Phase 1 Studies

Clinical Pharmacology in Drug Development, Volume 14, Issue 8, Page 572-582, August 2025.
Abstract Dazukibart is a humanized monoclonal antibody selectively targeting interferon‐β. The pharmacokinetics (PK), safety, tolerability, and immunogenicity of dazukibart were evaluated in 2 double‐blind, randomized, placebo‐controlled, single‐dose, Phase 1 studies in healthy adults in China (Study 1: N = 18; dazukibart 900 mg = 15; placebo = 3) and ...
Naihan Chen, Yamato Sano, Xiaohong Wang, Shuiyi Hu, Junichi Tabira, Xin Luo, Hiroki Yoshimatsu, John Prybylski, Myron Chu, Haiyan Li, Kenji Takazawa   +10 more
wiley   +1 more source

Chronotherapy and intervertebral disc degeneration: understanding the role of circadian rhythm in degenerative processes. [PDF]

Front Cell Dev Biol
Zhang C, Zhang R, Zhao G, Wu Z, Song W, Ran R, Zhou K, Zhang H.   +7 more
europepmc   +1 more source

Associations Between Sum Scores or Combinations of MRI Findings in the Lumbar Spine and Low Back Pain‐Related Outcomes: A Systematic Review

European Journal of Pain, Volume 29, Issue 7, August 2025.
ABSTRACT Background and Objective Research on lumbar MRI findings has mainly focused on single MRI findings and their association with low back pain (LBP). Some studies suggest that summing or combining MRI findings may show stronger associations with LBP than single findings.
Line Dragsbæk, Tue Secher Jensen, Per Kjær, Mark Hancock, Stine Clausen, Rikke Krüger Jensen   +5 more
wiley   +1 more source

Self-healing injectable multifunctional hydrogels for intervertebral disc disease. [PDF]

Mater Today Bio
Gu Z, He Y, Xiang H, Qin Q, Cao X, Jiang K, Zhang H, Li Y.   +7 more
europepmc   +1 more source

Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 8, August 2025.
Targeting ECM dysregulation: therapeutic strategies for disease intervention. Dysregulated ECM composition and biomechanics contribute to disease pathogenesis in cancer and fibrotic disorders. Physical modulation: Nanomedicine‐based strategies tune ECM physical properties (e.g., density, stiffness) to enhance drug penetration and therapeutic efficacy ...
Tian Zhao, Ye Huang, Jingfei Zhu, Yujie Qin, Hao Wu, Jiaxuan Yu, Qianwen Zhai, Shun Li, Xiang Qin, Dengfeng Wang, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

A Novel Approach to Predict the Location and Fatigue Life of Intervertebral Disc Degeneration. [PDF]

Bioengineering (Basel)
Zhang Z, Wang T, Bian H, Shen X, Liang M, Teo EC, Jiang T.   +6 more
europepmc   +1 more source

Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice. [PDF]

Bone Res
Ramteke P, Watson B, Toci M, Tran VA, Johnston S, Tsingas M, Barve RA, Mitra R, Loeser RF, Collins JA, Risbud MV.   +10 more
europepmc   +1 more source

Quercetin nanoformulation-embedded hydrogel inhibits osteopontin mediated ferroptosis for intervertebral disc degeneration alleviation. [PDF]

J Nanobiotechnology
Li J, Ren L, Wan L, Liu M, Zhao M, Lin Y, Zheng J, Tang Y, Luo Y, Ma Y, Wang L, Cao P, Chen Z, Ren W, Wang F.   +14 more
europepmc   +1 more source