Results 271 to 280 of about 93,770 (350)

Lobeglitazone improves glycaemic control as add‐on therapy to empagliflozin plus metformin in patients with type 2 diabetes mellitus: A double‐blind, randomised, placebo‐controlled trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 728-740, January 2026.
Abstract Aims This study aimed to evaluate the efficacy and safety of triple therapy with lobeglitazone 0.5 mg as an add‐on treatment compared with placebo in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin and empagliflozin.
Da Hea Seo, Kyung Wan Min, Ho Sang Sohn, Sang Yong Kim, In‐Kyung Jeong, Cheol‐Young Park, Kun‐Ho Yoon, So Hun Kim, Bong‐Soo Cha   +8 more
wiley   +1 more source

Screening and identification of differentially expressed miRNA and mRNA for intervertebral disc degeneration on bioinformatics. [PDF]

Eur J Med Res
Yan J, Gao Y, Chen R, Miao S, Gong Y, Zhu Y, Zhou Q.   +6 more
europepmc   +1 more source

Propionibacterium acnes evades microbicidal phagocytosis by inhibiting the mitochondrial biogenesis of nucleus pulposus cells

The FEBS Journal, Volume 293, Issue 1, Page 295-317, January 2026.
P. acnes infection impairs the mitochondrial biogenesis of nucleus pulposus cells (NPCs) through the AMPK/SIRT‐1/PGC‐1α signaling pathway. This results in impaired mitochondria that are unable to generate sufficient ATP, and impaired delivery of mitochondrial reactive oxygen species to carry out the bactericidal process effectively.
Lemeng Ren, Changwei Li, Juntao Sun, Yuehuan Zheng, Yucheng Jiao, Jiancheng Zheng, Fangke Zhang, Yazhou Lin, Wenjian Wu, Peng Cao   +9 more
wiley   +1 more source

Engineered Extracellular Vesicles for Intervertebral Disc Regeneration: Mechanisms, Strategies, and Translational Potential. [PDF]

Cureus
Wang J, Ran B, Wei J.
europepmc   +1 more source

Friedelin Ameliorates Nucleus Pulposus Inflammation by Increasing p65 Autophagic Degradation to Inhibit NF‐κB Signalling Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Intervertebral disc degeneration (IVDD) is a prevalent disorder associated with chronic inflammation, significantly affecting spinal health and general quality of life. This study examines the anti‐inflammatory properties of Friedelin (FD) and its impact on the NF‐κB signalling pathway in relation to IVDD.
Kewu Tu, Dongteng Liao, Zhaomou Chen, Zhenyu Wang, Kun Zhao, Hongyu Zhong, Shimin Wu, Huiyin Zhu, Jinming Xu, Beidi Zhou, Xiangheng Dai, Qiang Wu   +11 more
wiley   +1 more source

Based on the mechanism of degeneration of the small joint - muscle - intervertebral disc complex and early intervention. [PDF]

Ann Med Surg (Lond)
Wang S, Guo X, Li L, Shi J, Sun J, Guo Y.   +5 more
europepmc   +1 more source

Tuina Inhibits Synaptic Plasticity Through the Astrocytic NDRG2/GLT‐1 Pathway to Alleviate Neuropathic Pain

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT While Tuina has demonstrated clinical efficacy in alleviating neuropathic pain (NP) induced by peripheral nerve injury, the underlying molecular mechanisms remain unclear. Synaptic plasticity in the spinal dorsal horn (SDH) is a key regulator of pain processing, wherein astrocytes play a central role.
Huanzhen Zhang, Lechun Chen, Jingjing Jiang, Limei Huang, Hongye Huang, Lanting Huang, Shuijin Chen, Zhigang Lin   +7 more
wiley   +1 more source

Degenerative Disease of Intervertebral Disc: A Narrative Review of Pathogenesis, Clinical Implications and Therapies. [PDF]

Bioengineering (Basel)
Gradisnik L, Kocivnik N, Maver U, Velnar T.   +3 more
europepmc   +1 more source

Electroacupuncture Pretreatment Ameliorates Perioperative Neurocognitive Disorder in Aged Mice by Inhibiting Ferroptosis Through the SIRT1/NRF2/GPX4 Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Perioperative neurocognitive disorder (PND) is a common complication after anesthesia surgery in elderly patients, which not only reduces the patients' quality of life but also increases the burden on their families and society. PND has been found to be closely related to ferroptosis. This study investigated whether electroacupuncture (EA) can
Zhongying Du, Binsen Zhang, Tianren Chen, Chang Lei, Lu Tang, Sasa Yang, Chunai Wang   +6 more
wiley   +1 more source

Unraveling the causal landscape of intervertebral disc degeneration: A Mendelian randomization analysis of 108 traits. [PDF]

Medicine (Baltimore)
Zeng B, Xu S, Zhou D, Chen R, Ding Y, Wu Z, Zheng Z, Liu M, He B, Li S, Bao M.   +10 more
europepmc   +1 more source