Results 201 to 210 of about 23,413 (232)
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Myxomatous degeneration of the lumbar intervertebral disc
Neurosurgery, 1985Abstract Sixteen patients were operated on for lumbar pain and pain radiating into the sciatic nerve distribution. In all 16, when the anulus fibrosus was incised, soft, gray disc material extruded under pressure like toothpaste being squeezed from a tube.
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Genetic aspects of intervertebral disc degeneration
Reviews in the Neurosciences, 2015Abstract Intervertebral disc degeneration (IVDD) is one of the common causes of low back pain. Similar to many other multifactorial diseases, it is affected by environmental and genetic factors. Although not completely understood, genetic factors include a wide spectrum of variations, such as single nucleotide polymorphisms, which could ...
Sara, Hanaei +4 more
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Biochemical changes in intervertebral disc degeneration
Biochimica et Biophysica Acta (BBA) - General Subjects, 1981The distribution of the principal matrix components, collagen, proteoglycans and water, across the diameter of human normal and degenerate intervertebral discs was compared. Little difference in collagen distribution was noted between normal and degenerate tissue but water and proteoglycan content decreased with degeneration, particularly in the centre
G, Lyons, S M, Eisenstein, M B, Sweet
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Mechanobiology in intervertebral disc degeneration and regeneration
The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2005The intervertebral disc is an avascular, pliant, composite structure that separates spinal vertebrae and, in health, serves to support compression and facilitate movement. Its morphological organization is directed by fluid pressure and consists of a central swelling gel (nucleus), surrounded peripherally by a constraining ligament (annulus fibrosus ...
J C, Lotz +3 more
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The role of estrogen in intervertebral disc degeneration
Steroids, 2020Intervertebral disc degeneration (IVDD) is a main contributor to low back and radicular pain, which imposes heavy economic burdens on society. However, the etiology and mechanism of IVDD are complex and still not completely clear. In particular, the role of estrogen in IVDD has not received much attention in recent research, although estrogen plays a ...
Lin-Yu, Jin +2 more
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Mechanical Initiation of Intervertebral Disc Degeneration
Spine, 2000Mechanical testing of cadaveric lumbar motion segments.To test the hypothesis that minor damage to a vertebral body can lead to progressive disruption of the adjacent intervertebral disc.Disc degeneration involves gross structural disruption as well as cell-mediated changes in matrix composition, but there is little evidence concerning which comes ...
M A, Adams +4 more
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The molecular basis of intervertebral disc degeneration
The Spine Journal, 2013Intervertebral disc (IVD) degeneration remains a clinically important condition for which treatment is costly and relatively ineffective. The molecular basis of degenerative disc disease has been an intense focus of research recently, which has greatly increased our understanding of the biology underlying this process.To review the current ...
Christopher K, Kepler +4 more
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Molecular Basis of Intervertebral Disc Degeneration
2012Intervertebral disc (IVD) degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to degeneration of the disc and surrounding area. Degeneration of the disc is considered to be a normal process of aging, but can accelerate faster than expected or be precipitated by other factors.
Dipika, Gopal +3 more
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Aging and Degeneration of the Human Intervertebral Disc
Spine, 1995Human intervertebral discs undergo age-related degenerative changes that contribute to some of the most common causes of impairment and disability for middle aged and older persons: spine stiffness, neck pain, and back pain. Potential causes of the age-related degeneration of intervertebral discs include declining nutrition, loss of viable cells, cell ...
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Intervertebral disc cell biosynthesis in the degenerate and non-degenerate intervertebral disc
2015Conference Theme: Recent Advances and Challenges in Understanding Cartilage ...
Kudelko, MA +5 more
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