Results 181 to 190 of about 23,505 (207)

MMPs and ADAMTSs in intervertebral disc degeneration

Clinica Chimica Acta, 2015
Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with low back pain, a leading cause of musculoskeletal disability worldwide. The major components of extracellular matrix (ECM) within the discs are type II collagen (Col II) and aggrecan.
Wen-Jun, Wang, Xiao-Hua, Yu, Cheng, Wang, Wei, Yang, Wen-Si, He, Shu-Jun, Zhang, Yi-Guo, Yan, Jian, Zhang   +7 more
openaire   +2 more sources

Biochemical changes in intervertebral disc degeneration

Biochimica et Biophysica Acta (BBA) - General Subjects, 1981
The distribution of the principal matrix components, collagen, proteoglycans and water, across the diameter of human normal and degenerate intervertebral discs was compared. Little difference in collagen distribution was noted between normal and degenerate tissue but water and proteoglycan content decreased with degeneration, particularly in the centre
G, Lyons, S M, Eisenstein, M B, Sweet
openaire   +2 more sources

The molecular basis of intervertebral disc degeneration

The Spine Journal, 2013
Intervertebral disc (IVD) degeneration remains a clinically important condition for which treatment is costly and relatively ineffective. The molecular basis of degenerative disc disease has been an intense focus of research recently, which has greatly increased our understanding of the biology underlying this process.To review the current ...
Christopher K, Kepler, Ravi K, Ponnappan, Chadi A, Tannoury, Marakand V, Risbud, David G, Anderson   +4 more
openaire   +2 more sources

Molecular Basis of Intervertebral Disc Degeneration

2012
Intervertebral disc (IVD) degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to degeneration of the disc and surrounding area. Degeneration of the disc is considered to be a normal process of aging, but can accelerate faster than expected or be precipitated by other factors.
Dipika, Gopal, Allen L, Ho, Amol, Shah, John H, Chi   +3 more
openaire   +2 more sources

Aging and Degeneration of the Human Intervertebral Disc

Spine, 1995
Human intervertebral discs undergo age-related degenerative changes that contribute to some of the most common causes of impairment and disability for middle aged and older persons: spine stiffness, neck pain, and back pain. Potential causes of the age-related degeneration of intervertebral discs include declining nutrition, loss of viable cells, cell ...
openaire   +2 more sources

Intervertebral disc cell biosynthesis in the degenerate and non-degenerate intervertebral disc

2015
Conference Theme: Recent Advances and Challenges in Understanding Cartilage ...
Kudelko, MA, Cheah, KSE, Tam, V, Lam, YW, Chan, D, Sharma, R   +5 more
openaire   +1 more source

Nanobacteria and intervertebral disc degeneration

Medical Hypotheses, 2005
Hossein, Eskandary, Mohammad, Saba, Touraj, Yazdi   +2 more
openaire   +2 more sources

Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration

Cells, 2021
Zulma Gazit, Dan Gazit, Gadi Pelled
exaly  

Discogenic Low Back Pain: Anatomy, Pathophysiology and Treatments of Intervertebral Disc Degeneration

International Journal of Molecular Sciences, 2023
Isma Liza Mohd Isa, Seong Lin Teoh, Sabarul Afian Mokhtar   +2 more
exaly  

Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications

Journal of Inflammation Research, 2022
Hongfeng Ruan, Yuying Ge, Fangda Fu
exaly