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Epigenetic regulation in intervertebral disc degeneration
Trends in Molecular Medicine, 2022Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which has a striking impact on numerous patients. Therefore, comprehensively illuminating the regulatory mechanisms of IVD degeneration is of great significance. Here, we discuss the latest advances in understanding the main epigenetic mechanisms regulating IVD degeneration.
Gaocai Li +3 more
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Genetics of the Degenerated Intervertebral Disc
World Neurosurgery, 2012Given the genetic and proteomic advances of the past decade, understanding of the molecular etiopathogenesis of several complex diseases is increasing. Intervertebral disc disease (IVDD) is no different from other complex diseases where both environmental and genetic constituents are considered causes.
Samuel, Kalb +4 more
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Mechanobiology of the Intervertebral Disc and Relevance to Disc Degeneration
Journal of Bone and Joint Surgery, 2006Mechanical loading of the intervertebral disc may contribute to disc degeneration by initiating degeneration or by regulating cell-mediated remodeling events that occur in response to the mechanical stimuli of daily activity. This article is a review of the current knowledge of the role of mechanical stimuli in regulating intervertebral disc cellular ...
Lori A, Setton, Jun, Chen
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Imaging Intervertebral Disc Degeneration
Journal of Bone and Joint Surgery, 2006Magnetic resonance imaging provides excellent anatomic detail of spinal tissues, but fails to provide the type of information that permits a definitive diagnosis in many patients with back pain. New imaging strategies that can be applied to the study of intervertebral disc degeneration include diffusion-weighted imaging, magnetic resonance imaging ...
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Modern concepts of intervertebral disc degeneration
Voprosy neirokhirurgii imeni N.N. Burdenko, 2020The widespread prevalence of degenerative spine diseases and achievements in the treatment of these lesions have not yet led to an answer the main question: «What is the etiology of spine degeneration?» Treatment will remain symptomatic if primary cause of disease will be unclear. However, improvement of genetic and molecular survey gradually clarifies
A O, Gushcha, A R, Yusupova
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Pathogenesis of Intervertebral Disc Degeneration
2013It is estimated that as much as 84 % of the population will suffer from low back pain (LBP) at some point in their lifetime (Walker 2000), with around 10 % of sufferers being chronically disabled. As such LBP is one of the most prevalent musculoskeletal conditions affecting Western society (Stewart et al.
Hoyland, JA +2 more
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Mechanobiology in intervertebral disc degeneration and regeneration
The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2005The intervertebral disc is an avascular, pliant, composite structure that separates spinal vertebrae and, in health, serves to support compression and facilitate movement. Its morphological organization is directed by fluid pressure and consists of a central swelling gel (nucleus), surrounded peripherally by a constraining ligament (annulus fibrosus ...
J C, Lotz +3 more
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Myxomatous degeneration of the lumbar intervertebral disc
Neurosurgery, 1985Abstract Sixteen patients were operated on for lumbar pain and pain radiating into the sciatic nerve distribution. In all 16, when the anulus fibrosus was incised, soft, gray disc material extruded under pressure like toothpaste being squeezed from a tube.
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Mechanical Initiation of Intervertebral Disc Degeneration
Spine, 2000Mechanical testing of cadaveric lumbar motion segments.To test the hypothesis that minor damage to a vertebral body can lead to progressive disruption of the adjacent intervertebral disc.Disc degeneration involves gross structural disruption as well as cell-mediated changes in matrix composition, but there is little evidence concerning which comes ...
M A, Adams +4 more
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The role of estrogen in intervertebral disc degeneration
Steroids, 2020Intervertebral disc degeneration (IVDD) is a main contributor to low back and radicular pain, which imposes heavy economic burdens on society. However, the etiology and mechanism of IVDD are complex and still not completely clear. In particular, the role of estrogen in IVDD has not received much attention in recent research, although estrogen plays a ...
Lin-Yu, Jin +2 more
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