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Notch signaling-targeted biomimetic hydrogel constructs an anti-inflammatory "flood-control" system to alleviate pyroptosis for intervertebral disc degeneration treatment. [PDF]

Mater Today Bio
Zhang R, Zhang X, Guo J, Yang Y, Niu J, Shen H, Zheng Y, Wang J, Wang S, Ni L, Yang H, Shi Q.   +11 more
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Intervertebral disc degeneration in the dog. Part 1: Anatomy and physiology of the intervertebral disc and characteristics of intervertebral disc degeneration

Veterinary Journal, 2013
Intervertebral disc (IVD) degeneration is common in dogs and can give rise to a number of diseases, such as IVD herniation, cervical spondylomyelopathy, and degenerative lumbosacral stenosis. Although there have been many reports and reviews on the clinical aspects of canine IVD disease, few reports have discussed and reviewed the process of IVD ...
Björn Meij, Guy Grinwis, Marianna Tryfonidou   +2 more
exaly   +3 more sources

Genetic aspects of intervertebral disc degeneration

Reviews in the Neurosciences, 2015
Abstract Intervertebral disc degeneration (IVDD) is one of the common causes of low back pain. Similar to many other multifactorial diseases, it is affected by environmental and genetic factors. Although not completely understood, genetic factors include a wide spectrum of variations, such as single nucleotide polymorphisms, which could ...
Alireza Khoshnevisan, Nima Rezaei, Sara Hanaei   +2 more
exaly   +3 more sources

Genetics of Intervertebral Disc Degeneration

Current Osteoporosis Reports, 2023
Intervertebral disc degeneration is a contributor to chronic back pain. While a part of the natural aging process, early or rapid intervertebral disc degeneration is highly heritable. In this review, we summarize recent progress towards unraveling the genetics associated with this degenerative process.Use of large cohorts of patient data to conduct ...
David C. Ou-Yang, Christopher J. Kleck, Cheryl L. Ackert-Bicknell   +2 more
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Fundamentals of Intervertebral Disc Degeneration

World Neurosurgery, 2022
Lumbar disc degeneration is one of the leading causes of chronic low back pain. The degenerative cascade is often initiated by an imbalance between catabolic and anabolic processes in the intervertebral discs. As a consequence of extracellular matrix degradation, neoinnervation and neovascularization take place.
Sertac Kirnaz, Charisse Capadona, Taylor Wong, Jacob L. Goldberg, Branden Medary, Fabian Sommer, Lynn B. McGrath, Roger Härtl   +7 more
openaire   +2 more sources

Intervertebral disc degeneration

Nature Reviews Disease Primers
Intervertebral disc (IVD) degeneration is a naturally occurring process that is a consequence of biological ageing and exposure to normal physiological loading over a lifetime and is characterized by loss of IVD tissue structural integrity. The nucleus pulposus changes with loss of pressurization, decreased collagen concentration and loss of ...
Bradley T. Hammoor, Christopher S. Lai, Grace X. Xiong, Dawn M. Elliott, Brian Snyder, Edward Vresilovic, Christopher M. Bono, Benjamin R. Freedman   +7 more
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Intervertebral disc degeneration

European Spine Journal, 1993
Disc degeneration in the human spine is a complex phenomenon characterised by biochemical change in the nucleus pulposus and inner annulus and the formation of clefts and fissures radiating from the central area of the disc towards the periphery. In addition, and probably independent of these phenomena, discrete defects in the outer annular attachement
R D, Fraser, O L, Osti, B, Vernon-Roberts   +2 more
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Smoking and intervertebral disc degeneration

Medical Hypotheses, 2001
Cigarette smokers have an increased risk of low back pain which may be caused by disc degeneration and spinal instability, for example. Ischemia, apoptosis, faulty synthesis of disc macromolecules, and an imbalance between disc matrix proteinases and their inhibitors may be involved in the pathogenesis of disc degeneration. Along with degeneration, the
R R, Fogelholm, A V, Alho
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