Results 141 to 150 of about 39,314 (264)

Intervertebral disc degeneration, inflammation, and bioactive lipids

Recent Trends in Pharmacology
Intervertebral disc degeneration, inflammation, and bioactive lipidsIntervertebral disc degenerationIntervertebral disc (IVD) degeneration is a common condition that is associated with significant morbidity.
Undurti Das, Ahmet Hacımüftüoğlu
doaj   +1 more source

Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease

Immunology, Volume 178, Issue 2, Page 218-230, June 2026.
This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley   +1 more source

Dilated Cardiomyopathy and Aortic Thrombosis in a Capuchin Monkey (Sapajus apella)

Journal of Medical Primatology, Volume 55, Issue 3, June 2026.
ABSTRACT This case report describes a capuchin monkey (Sapajus apella) that presented with bilateral paralysis and cold hind limbs. Clinical examination, including ultrasound imaging, revealed dilated cardiomyopathy and aortic thrombosis. Macroscopic, histopathological, and immunohistochemical analyses confirmed these findings.
Christiane Helm, Andreas Bracke, Jens Peter Teifke, Reiner Ulrich   +3 more
wiley   +1 more source

Efficacy and Safety of the Use of Interspinous Spacers in the Treatment of Lumbar Spinal Stenosis: Mapping Gap and Scoping Review

Pain Practice, Volume 26, Issue 5, June 2026.
ABSTRACT Objectives Low back pain is a common pathology in the general population. In people over 60 years of age, it is associated with degenerative changes that cause narrowing of the vertebral canal. Its treatment includes conservative measures and even surgery with decompression and fusion.
Juan Carlos Acevedo‐Gonzalez, Valentina Velasco‐Muñoz, Juan Jacobo Ramirez‐Triana, Danuby Adriana Buitrago‐Lopez   +3 more
wiley   +1 more source

A Novel Scoring System for Predicting Procedural Difficulty in Supraneural L5 TFESI: The L5 TFESI Difficulty Score (LTDS)

Pain Practice, Volume 26, Issue 5, June 2026.
ABSTRACT Introduction Supraneural transforaminal epidural steroid injections (TFESI) at the L5 level are widely used to manage lumbosacral radiculopathy. However, fluoroscopic barriers such as prominent osteophytes and altered transverse process morphology can complicate needle advancement and reduce the likelihood of optimal injectate delivery ...
Chul Kim, Jun Hyeong Song
wiley   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

A Decade of Leadership and Impact: Celebrating 10 Years of the ORS Spine Section

JOR SPINE, Volume 9, Issue 2, June 2026.
Neharika Bhadouria, Rahul Gawri, Gabriela Graziani, Dennis E. Anderson, Ana V. Chee, Chitra L. Dahia, Ashish Diwan, Morgan B. Giers, Svenja Illien‐Junger, Anthony Kirilusha, David J. Nuckley, Derek H. Rosenzweig, Cheryle Séguin, Dmitriy Sheyn, Graciosa Q. Teixeira, Mauro Alini, Keita Ito, Robert L. Mauck, Daisuke Sakai, Jeannie Bailey, Aaron J. Fields, Sibylle Grad, Sarah E. Gullbrand, Nilsson Holguin, Rita Kandel, Zhen Li, Joshua Li, John T. Martin, Fackson Mwale, Grace D. O'Connell, Devina Purmessur, Nam Vo, Uruj Zehra, Nadeen O. Chahine, Lisbet Haglund, Judith A. Hoyland, Christine L. Le Maitre, Jeffrey C. Lotz, Makarand V. Risbud, Lachlan J. Smith, Simon Tang, James C. Iatridis, Karin Wuertz‐Kozak, Dino Samartzis   +43 more
wiley   +1 more source

Surgical Resection of Lumbar Spine Osteoblastoma With Secondary Aneurysmal Bone Cysts Through a Combined Transpsoas and Posterior Approach: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Aggressive lumbar osteoblastoma with secondary aneurysmal bone cysts is rare and may involve both posterior elements and vertebral bodies. When extensive multilevel involvement is present, a combined posterior and transpsoas approach can facilitate complete tumor resection, restore spinal stability, and achieve favorable neurological and ...
Enliang Chen, Daxuan Liang, Xiaodong Li, Xiaobao Zou, Chenfu Deng, Junlin Chen, Rencai Ma, Xiangyang Ma, Junjie Xu   +8 more
wiley   +1 more source

Tissue‐Level Neck Response in Rotary‐Wing Aircrew With Head‐Supported Mass Assessed With Finite Element Model

International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 5, May 2026.
Rotary‐wing aircrew have reported the occurrence of neck pain, potentially associated with rapid scanning tasks and head‐supported mass (HSM). The aim of this study is to gain additional insight into the interaction of HSM and neck positions with the innervated tissues in the neck.
Prasannaah Hadagali, Steven L. Fischer, Jack P. Callaghan, Duane S. Cronin   +3 more
wiley   +1 more source

Inhibition of ASIC1a Attenuates Neuronal Pyroptosis and Neuroinflammation Following Traumatic Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
This study identifies ASIC1a as a key modulator of neuroinflammation following traumatic brain injury. Pharmacological inhibition of ASIC1a mitigates neuronal pyroptosis and improves neurological outcomes, a protective effect closely associated with the downregulation of the NF‐κB/NLRP3 signaling axis.
Jiawei Liang, Peng Chen, Yangyang Zhao, Pan Lei, Yulong Li, Yichen Zhang, Jia‐hong Cai, Yong‐an Jiang, Yan Zhang, Shiqi Cheng   +9 more
wiley   +1 more source