Results 131 to 140 of about 23,413 (232)

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

Inhibition of Fibroblast Activation Protein‐α Ameliorates Intervertebral Disc Degeneration via Reduced Vascular Invasion in Cartilage Endplate

Cell Proliferation, Volume 59, Issue 6, June 2026.
Schematic illustration showing that FAP‐α promoted angiogenesis, cytokine release and ECM degradation in the CEP degeneration of the intervertebral disc through upregulating the PI3K/Akt/HIF‐1α/VEGFA pathway. ABSTRACT Intervertebral disc degeneration (IDD) is a primary cause of low back pain, with the development of new blood vessels being a key ...
Hao‐Wei Xu, Sheng‐Jie Chang, Shuo Wang, Xiao‐Wei Liu, Shan‐Jin Wang   +4 more
wiley   +1 more source

Role of Autophagy and Pyroptosis in Intervertebral Disc Degeneration

Journal of Inflammation Research
Zhiqiang Wang,* Xiaochun Li,* Pengfei Yu,* Yu Zhu, Feng Dai, Zhijia Ma, Xueqiang Shen, Hong Jiang, Jintao Liu Department of Orthopedic Surgery, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009, People’s
Wang Z, Li X, Yu P, Zhu Y, Dai F, Ma Z, Shen X, Jiang H, Liu J   +8 more
doaj  

Ovine models of intervertebral disc degeneration. [PDF]

Ann Transl Med
Bonilla AF, Seim HB, Gadomski B, Patel VV, Easley JT.   +4 more
europepmc   +1 more source

Current Perspective on Orthobiology Applications for the Treatment of Intervertebral Disc Degeneration (IDD)-A Narrative Review. [PDF]

Medicina (Kaunas)
Conza G, Trotta MC, Mastronardi C, Nocera A, Itro A, Martin G, Toro G, Lepre CC, Russo M, Toro G.   +9 more
europepmc   +1 more source

Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease

Immunology, Volume 178, Issue 2, Page 218-230, June 2026.
This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley   +1 more source

Biomaterial-based strategies targeting ferroptosis for alleviating intervertebral disc degeneration: Advances and perspectives. [PDF]

J Orthop Translat
Fu Y, Wang Z, Wang W, Xie Y, Chen L, Tan L, Liu M.   +6 more
europepmc   +1 more source

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

Ubiquitination in intervertebral disc degeneration: from mechanisms to potential therapeutic strategies. [PDF]

J Orthop Translat
Liu X, Kang X.
europepmc   +1 more source

Dilated Cardiomyopathy and Aortic Thrombosis in a Capuchin Monkey (Sapajus apella)

Journal of Medical Primatology, Volume 55, Issue 3, June 2026.
ABSTRACT This case report describes a capuchin monkey (Sapajus apella) that presented with bilateral paralysis and cold hind limbs. Clinical examination, including ultrasound imaging, revealed dilated cardiomyopathy and aortic thrombosis. Macroscopic, histopathological, and immunohistochemical analyses confirmed these findings.
Christiane Helm, Andreas Bracke, Jens Peter Teifke, Reiner Ulrich   +3 more
wiley   +1 more source