Results 111 to 120 of about 23,413 (232)

Uncertainty Quantification of Central Canal Stenosis Deep Learning Classifier From Lumbar Sagittal T2‐Weighted MRI

JOR SPINE, Volume 9, Issue 2, June 2026.
ABSTRACT Background Accurate assessment of the severity of central canal stenosis (CCS) on lumbar spine MRI is critical for clinical decision‐making. We evaluated deep learning models for automated CCS grading on sagittal T2‐weighted MRI, focusing on uncertainty quantification to improve clinical reliability.
Adriana Brenzikofer, Maria Monzon, Fabio Galbusera, Zina‐Mary Manjaly, Andrea Cina, Catherine R. Jutzeler   +5 more
wiley   +1 more source

Lifetime Physical Loading and Magnetic Resonance‐Derived Intervertebral Disc Health in Adults With Chronic Low Back Pain: A Cross‐Sectional Study

JOR SPINE, Volume 9, Issue 2, June 2026.
Final multiple linear regression model: heat maps showing Bone‐specific Physical Activity Questionnaire score associations with T2 values in five intervertebral disc (IVD) regions with statistically significant covariates controlled for at individual spinal levels.
Claire L. Samanna, Christopher Neason, Scott D. Tagliaferri, Ulrike H. Mitchell, Michelle Caldwell, Ali Imran, Hana Rae Nez, Daniel L. Belavý, Clint T. Miller, David Scott, Niamh L. Mundell, Paul Buntine, Patrick J. Owen   +12 more
wiley   +1 more source

Quantitative Disk and Metabolic Bone PET‐MRI for Understanding Disk‐Endplate Crosstalk in Degeneration of the Lumbar Spine

JOR SPINE, Volume 9, Issue 2, June 2026.
ABSTRACT Objectives The aim of this investigation was to explore the association between disk degeneration, quantified by Pfirrmann grades and T1rho as a marker of hydration, and bone remodeling in the vertebral endplate quantified by Na[18F]F uptake on PET.
Virginie Kreutzinger, Katharina Ziegeler, Misung Han, Cynthia T. Chin, Rupsa Bhattacharjee, Isabelle Remick, Emma Bahroos, Sharmila Majumdar   +7 more
wiley   +1 more source

Application of Statistical Shape Models to Standard Lumbar MRI for Stenosis Treatment Stratification: Severe Versus Normal Stenosis

JOR SPINE, Volume 9, Issue 2, June 2026.
Statistical shape models (SSMs) derived from standard 2D lumbar MRIs capture coordinated morphological features that distinguish severe from normal spinal stenosis. Both intervertebral disc and combined models provide strong discriminatory power, comparable to or exceeding traditional anatomical measurements.
Mary H. Foltz, Alexandra Seidenstein, Wesley M. Durand, Amit Jain, Jill M. Middendorf   +4 more
wiley   +1 more source

MRI T2 Relaxation Time of the Intervertebral Disc: Repeatability, the Effect of Time of Day, and Unloaded Rest

JOR SPINE, Volume 9, Issue 2, June 2026.
T2 relaxation time is a commonly used MRI measure of intervertebral disc degeneration. This study investigated the repeatability, as well as the effects of time of day and rest on T2 relaxation time. T2 time repeatability was primarily driven by acquisition factors while time of day and rest changes did not exceed within subject variability. Thus, this
Mackenzie N. Conner, Harrah R. Newman, John M. Peloquin, Edward J. Vresilovic, Dawn M. Elliott   +4 more
wiley   +1 more source

Diagnostic Features of Discogenic Low Back Pain: A Narrative Review and Suggested Areas for Future Research and Clinical Practice

JOR SPINE, Volume 9, Issue 2, June 2026.
ABSTRACT Background Chronic low back pain is a leading cause of global disability, with discogenic low back pain (DLBP), mechanically stimulated pain arising from the intervertebral disc, representing an important but often under‐recognized subtype. DLBP arises from chronic structural and metabolic changes within the intervertebral disc, leading to ...
William Roger Peters, Ashish D. Diwan, Mario Giuseppe Zotti   +2 more
wiley   +1 more source

A Decade of Leadership and Impact: Celebrating 10 Years of the ORS Spine Section

JOR SPINE, Volume 9, Issue 2, June 2026.
Neharika Bhadouria, Rahul Gawri, Gabriela Graziani, Dennis E. Anderson, Ana V. Chee, Chitra L. Dahia, Ashish Diwan, Morgan B. Giers, Svenja Illien‐Junger, Anthony Kirilusha, David J. Nuckley, Derek H. Rosenzweig, Cheryle Séguin, Dmitriy Sheyn, Graciosa Q. Teixeira, Mauro Alini, Keita Ito, Robert L. Mauck, Daisuke Sakai, Jeannie Bailey, Aaron J. Fields, Sibylle Grad, Sarah E. Gullbrand, Nilsson Holguin, Rita Kandel, Zhen Li, Joshua Li, John T. Martin, Fackson Mwale, Grace D. O'Connell, Devina Purmessur, Nam Vo, Uruj Zehra, Nadeen O. Chahine, Lisbet Haglund, Judith A. Hoyland, Christine L. Le Maitre, Jeffrey C. Lotz, Makarand V. Risbud, Lachlan J. Smith, Simon Tang, James C. Iatridis, Karin Wuertz‐Kozak, Dino Samartzis   +43 more
wiley   +1 more source

Comparative Analysis of Dual‐miRNA Mediated Stimulation of Nucleus Pulposus and Bone Marrow Derived Stem Cells for Intervertebral Disc Repair

JOR SPINE, Volume 9, Issue 2, June 2026.
Nucleus pulposus (NP) and bone marrow derived stem cells (BMSCs) transfected with miRNA‐149‐5p‐mimic and 221‐3p‐inhibitor were evaluated in goat monolayer, microtissue, and ex vivo organ cultures of mild degeneration. miRNA‐treated NP cells demonstrated an anti‐catabolic and pro‐discogenic response in organs, highlighting its potential as a ...
Tara Ní Néill, Niamh Wilson, Jake McDonnell, Fergal J. O'Brien, Caroline M. Curtin, James E. Dixon, Pieter A. J. Brama, Conor T. Buckley   +7 more
wiley   +1 more source

Pre‐Conditioned Bone Marrow Mesenchymal Stromal Cell‐Derived Secretome Exerts an Anti‐Inflammatory Effect on Degenerative Nucleus Pulposus Cells In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
IL‐1β‐preconditioned BM‐MSC‐derived secretome counteracts inflammation‐driven degeneration in hNPCs. BM‐MSCs were preconditioned with IL‐1β (10 ng/mL) for 24 h, and the resulting secretome (BM‐MSCsec) was collected. Degenerative hNPCs cultured in a 3D alginate bead model were exposed to IL‐1β to reproduce an inflammatory degenerative microenvironment ...
Veronica Tilotta, Gianluca Vadalà, Luca Ambrosio, Giuseppina Di Giacomo, Claudia Cicione, Fabrizio Russo, Rocco Papalia, Vincenzo Denaro   +7 more
wiley   +1 more source

Defining the Human Nucleus Pulposus Microenvironment and Its Impact on Cell Matrix Synthesis and Metabolic Activity

JOR SPINE, Volume 9, Issue 2, June 2026.
Human intervertebral disc nutrient microenvironment. Changes observed in microenvironmental profile as a result of degeneration outlined on upper vertebral body with ranges of each species as reported in previous studies. Oxygen, glucose, and lactate gradients are profiled across the lower disc in both healthy and degenerated states.
Niamh Wilson, Tara Ní Néill, Jake McDonnell, Emily McDonnell, Stacey Darwish, Joseph S. Butler, Conor T. Buckley   +6 more
wiley   +1 more source